Growth factors improve muscle healing in vivo.

Growth factors improve muscle healing in vivo. Research Abstract Details 

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Growth factors improve muscle healing in vivo. Abstract Text:

J Menetrey,C Kasemkijwattana,C S Day,P Bosch,M Vogt,F H Fu,M S Moreland,J Huard,

Injury to muscles is very common. We have previously observed that basic fibroblast growth factor (b-FGF), insulin growth factor type 1 (IGF-1) and nerve growth factor (NGF) are potent stimulators of the proliferation and fusion of myoblasts in vitro. We therefore injected these growth factors into mice with lacerations of the gastrocnemius muscle. The muscle regeneration was evaluated at one week by histological staining and quantitative histology. Muscle healing was assessed histologically and the contractile properties were measured one month after injury. Our findings showed that b-FGF, IGF and to a less extent NGF enhanced muscle regeneration in vivo compared with control muscle. At one month, muscles treated with IGF-1 and b-FGF showed improved healing and significantly increased fast-twitch and tetanus strengths. Our results suggest that b-FGF and IGF-1 stimulated muscle healing and may have a considerable effect on the treatment of muscle injuries.

Growth factors improve muscle healing in vivo. Publishing Authors By Initials

J Menetrey,C Kasemkijwattana,CS Day,P Bosch,M Vogt,FH Fu,MS Moreland,J Huard,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Growth factors improve muscle healing in vivo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of bone and joint surgery. British vol

VOLUME: 82

Page Numbers: 131-7

Journal Abbreviation:

ISSN: 0301-620X

DAY: 14

MONTH: Jan

YEAR: 2000

Growth factors improve muscle healing in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 375355

Growth factors improve muscle healing in vivo. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: physiology

Chemical & Substance for Abstract: Growth factors improve muscle healing in vivo. Information

Substance Name: Nerve Growth Factor

Registry Number: 9061-61-4

Grant and Affiliation Information for Growth factors improve muscle healing in vivo.

AFFILIATION: Department of Orthopaedic Surgery, Musculoskeletal Research Centre, Children's Hospital of Pittsburgh and the University of Pittsburgh, Pennsylvania 15261, USA.

Country: ENGLAND

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MEDLINETA: J Bone Joint Surg Br

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