Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. Research Abstract Details 

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Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. Abstract Text:

Kazuhide Watanabe,Caterina Bianco,Luigi Strizzi,Shin Hamada,Mario Mancino,Veronique Bailly,Wenjun Mo,Dingyi Wen,Konrad Miatkowski,Monica Gonzales,Michele Sanicola,Masaharu Seno,David S Salomon,Kazuhide Watanabe,Caterina Bianco,Luigi Strizzi,Shin Hamada,Mario Mancino,Veronique Bailly,Wenjun Mo,Dingyi Wen,Konrad Miatkowski,Monica Gonzales,Michele Sanicola,Masaharu Seno,David S Salomon,

Cripto-1 (CR-1) is a glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein that has been shown to play an important role in embryogenesis and cellular transformation. CR-1 is reported to function as a membrane-bound co-receptor and as a soluble ligand. Although a number of studies implicate the role of CR-1 as a soluble ligand in tumor progression, it is unclear how transition from the membrane-bound to the soluble form is physiologically regulated and whether differences in biological activity exist between these forms. Here, we demonstrate that CR-1 protein is secreted from tumor cells into the conditioned medium after treatment with serum, epidermal growth factor, or lysophosphatidic acid, and this soluble form of CR-1 exhibits the ability to promote endothelial cell migration as a paracrine chemoattractant. On the other hand, membrane-bound CR-1 can stimulate endothelial cell sprouting through direct cell-cell interaction. Shedding of CR-1 occurs at the GPI-anchorage site by the activity of GPI-phospholipase D (GPI-PLD), because CR-1 shedding was suppressed by siRNA knockdown of GPI-PLD and enhanced by overexpression of GPI-PLD. These findings describe a novel molecular mechanism of CR-1 shedding, which may contribute to endothelial cell migration and possibly tumor angiogenesis.

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. Publishing Authors By Initials

K Watanabe,C Bianco,L Strizzi,S Hamada,M Mancino,V Bailly,W Mo,D Wen,K Miatkowski,M Gonzales,M Sanicola,M Seno,DS Salomon,K Watanabe,C Bianco,L Strizzi,S Hamada,M Mancino,V Bailly,W Mo,D Wen,K Miatkowski,M Gonzales,M Sanicola,M Seno,DS Salomon,

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Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: The Journal of biological chemistry

VOLUME: 282

Page Numbers: 31643-55

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 24

MONTH: 08

YEAR: 2007

Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration. Information

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LANGUAGE: eng

NlmUniqueID: 2985121

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Grant and Affiliation Information for Growth factor induction of Cripto-1 shedding by glycosylphosphatidylinositol-phospholipase D and enhancement of endothelial cell migration.

AFFILIATION: Tumor Growth Factor Section, Mammary Biology & Tumorigenesis Laboratory, Center for Cancer Research, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

Country: United States

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MEDLINETA: J Biol Chem

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