Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex.

Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex. Abstract Text:

Z Mateo,J T Porter,

Thalamocortical synapses provide a strong glutamatergic excitation to cortical neurons that is critical for processing sensory information. Unit recordings in vivo indicate that metabotropic glutamate receptors (mGluRs) reduce the effect of thalamocortical input on cortical circuits. However, it is not known whether this reduction is due to a reduction in glutamate release from thalamocortical terminals or from a decrease in cortical neuron excitability. To directly determine whether mGluRs act as autoreceptors on thalamocortical terminals, we examined the effect of mGluR agonists on thalamocortical synapses in slices. Thalamocortical excitatory postsynaptic currents (EPSCs) were recorded in layer IV cortical neurons in developing mouse brain slices. The activation of group II mGluRs with (2S,2'R,3'R)-2-(2',3'-dicarboxycyclopropyl)glycine (DCG IV) reduced thalamocortical EPSCs in both excitatory and inhibitory neurons, while the stimulation of group I or group III mGluRs had no effect on thalamocortical EPSCs. Consistent with a reduction in glutamate release, DCG IV increased the paired pulse ratio and the coefficient of variation of the EPSCs. The reduction induced by DCG IV was reversed by the group II mGluR antagonist, LY341495, and mimicked by another selective group II agonist, (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (APDC). The mGluR2 subtype appears to mediate the reduction of thalamocortical EPSCs, since the selective mGluR3 agonist, N-acetylaspartylglutamate (NAAG), had no effect on the EPSCs. Consistent with this, we showed that mGluR2 is expressed in the barrels. Furthermore, blocking group II mGluRs with LY341495 reduced the synaptic depression induced by a short stimulus train, indicating that synaptically released glutamate activates these receptors. These results indicate that group II mGluRs modulate thalamocortical processing by inhibiting glutamate release from thalamocortical synapses. This inhibition provides a feedback mechanism for preventing excessive excitation of cortical neurons that could play a role in the plasticity and refinement of thalamocortical connections during this early developmental period.

Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex. Publishing Authors By Initials

Z Mateo,JT Porter,

For similar heterocyclic compounds: heterocyclic compounds, 3-ring: xanthenes research abstracts see: heterocyclic compounds: heterocyclic compounds, 3-ring: xanthenes research

PUBMED ID PMID:

MEDLINE DATE:

Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neuroscience

VOLUME: 146

Page Numbers: 1062-72

Journal Abbreviation: Neuroscience

ISSN: 0306-4522

DAY: 6

MONTH: 04

YEAR: 2007

Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7605074

Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex. Keywords Mesh Terms:

KEYWORDS: Xanthenes

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex.

AFFILIATION: Department of Physiology, Pharmacology and Toxicology, Ponce School of Medicine, PO Box 7004, Ponce, Puerto Rico 00732.

Country: United States

AGENCY: United States NIGMS

GRANT: S06 GM08239

ACRONYM: GM

MEDLINETA: Neuroscience

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex Related Publications

• 1157.
• Actions taken by frail older widows to allow home care providers access to their homes.
• Alpha1A-adrenergic receptors are functionally expressed by a subpopulation of cornu ammonis 1 interneurons in rat hippocampus.
• Chemical and statistical considerations in the determination of partition coefficients of weakly ionizable drugs and poisons.
• Commentary.
• Discovery and SAR studies of novel GlyT1 inhibitors.
• Do interventions to increase income improve the health of the poor in developed economies and are such policies cost effective?
• Enhancing Short-Term RecoverY after High Intensity Anaerobic Exercise: 1835: Board #123 May 31 9:00 AM 10:30 AM.
• Examination of the role of intestinal fatty acid-binding protein in drug absorption using a parallel artificial membrane permeability assay.
• Extranodal NK/T-cell lymphoma, nasal type.
• GLOBAL INITIATIVE The Economic Case.
• Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA.
• Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex.
• Hepatic cytochrome P450 reductase-null mice reveal a second microsomal reductase for squalene monooxygenase.
• In vivo and in vitro lipid peroxidation of arachidonate esters: the effect of fish oil omega-3 lipids on product distribution.
• Inhibition of breast cancer growth and invasion by single-minded 2s.
• Measurement of driving patterns of older adults using data logging devices with and without global positioning system capability.
• Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones.
• Phospholipid-protein adducts of lipid peroxidation: synthesis and study of new biotinylated phosphatidylcholines.
• Polyamine metabolism and tumorigenesis in the Apc(Min/+) mouse.
• Postoperative radiographs following hip fracture surgery. Do they influence patient management?
• Predicting diabetic ketoacidosis in children by measuring end-tidal CO2 via non-invasive nasal capnography.
• Regression of myelofibrosis and osteosclerosis following hematopoietic cell transplantation assessed by magnetic resonance imaging and histologic grading.
• Target practice. In search engine marketing, opportunity outweighs risk.
• Tetrahydro-1,8-naphthyridinol analogues of alpha-tocopherol as antioxidants in lipid membranes and low-density lipoproteins.
• The medial surgical approach to the humerus.
• The unclear role of ethnicity in health inequalities: the scenario of oral cancer incidence and survival in the British South Asian population.
• Treatment of upper tract urothelial carcinoma: a review of surgical and adjuvant therapy.
• Use of Global Positioning System (GPS) Watches and Accelerometry to Monitor Mobility in Older Adults: 628: May 30 4:30 PM 4:45 PM.
• Validity, trustworthiness and rigour: reasserting realism in qualitative research.