Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone.

Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone. Abstract Text:

Weibin Chen,Cynthia S Day,S Bruce King,

An intramolecular hetero-Diels-Alder cycloadduct of an acyl nitroso compound and a 9,10-dimethyl anthracene derivative was prepared as a potential nitroxyl (HNO) donor. This compound did not release HNO under any of the conditions tested. Treatment of this cycloadduct with excess MeMgCl resulted in the formation of a nitrone, whose structure was confirmed by X-ray crystallography. A mechanism where MeMgCl acts as a nucleophile, strong base, and Lewis acid possibly explains the formation of this product.

Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone. Publishing Authors By Initials

W Chen,CS Day,SB King,

For similar organic chemicals: nitroso compounds research abstracts see: organic chemicals: nitroso compounds research

PUBMED ID PMID:

MEDLINE DATE:

Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of organic chemistry

VOLUME: 71

Page Numbers: 9221-4

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 24

MONTH: Nov

YEAR: 2006

Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985193

Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone. Keywords Mesh Terms:

KEYWORDS: Nitroso Compounds

MESH TERMS: chemistry

Chemical & Substance for Abstract: Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone. Information

Substance Name: anthracene

Registry Number: 120-12-7

Grant and Affiliation Information for Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone.

AFFILIATION: Department of Chemistry, Wake Forest University, Winston-Salem, North Carolina 27109, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 62198

ACRONYM: HL

MEDLINETA: J Org Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Grignard reagent-mediated conversion of an acyl nitroso-anthracene cycloadduct to a nitrone Related Publications

• A satisfaction enhancement intervention for long-term weight loss.
• A systematic literature review of tobacco use among adults 15 years and older in sub-Saharan Africa.
• Coloring our eyes.
• Computational study of the contribution of the vasculature on the dynamic response of the brain.
• Cytogenetic analysis of Day-4 embryos from PMSG/hCG-treated prepuberal gilts.
• Death by survey: estimating adult mortality without selection bias from sibling survival data.
• Dynamic regulation of single- and mixed-species malaria infection: insights to specific and non-specific mechanisms of control.
• Early recurrence of an intracranial epidermoid cyst due to low-grade infection: case report.
• Factors that shape young people's sexual behaviour: a systematic review.
• Glutamine deamidation destabilizes human gammaD-crystallin and lowers the kinetic barrier to unfolding.
• Hydrolysis of acyloxy nitroso compounds yields nitroxyl (HNO).
• Idiopathic interstitial pneumonias: progress in classification, diagnosis, pathogenesis and management.
• Impacting policy through science and education.
• Incorporation of system resolution compensation (RC) in the ordered-subset transmission (OSTR) algorithm for transmission imaging in SPECT.
• Mechanical characterization of porcine abdominal organs.
• Morphological study of the bovine blastocyst with phase contrast microscopy.
• Prenatal malaria immune experience affects acquisition of Plasmodium falciparum merozoite surface protein-1 invasion inhibitory antibodies during infancy.
• Progesterone and luteinizing hormone profiles in heifers used as oocyte donors.
• Reduction in antimicrobial substantivity of MTAD after initial sodium hypochlorite irrigation.
• Regio- and stereospecific syntheses and nitric oxide donor properties of (E)-9- and (E)-10-nitrooctadec-9-enoic acids.
• Reproductive performance of Polwarth and corriedale sheep in Tasmania.
• Simultaneous assessment of cardiac perfusion and function using 5-dimensional imaging with Tc-99m teboroxime.
• Streptomycin and dihydrostreptomycin; applied pharmacology.
• Stress versus discrete negative emotions in the prediction of physical complaints: does predictive utility vary across ethnic groups?
• Structural Response of Lower Leg Muscles in Compression: A Low Impact Energy Study Employing Volunteers, Cadavers and the Hybrid III.
• The impact of group size on memory and memory beliefs: a methodological report.
• The importance of drug delivery to optimize the effects of bone morphogenetic proteins during periodontal regeneration.
• Tourette syndrome: the self under siege.
• Use of three-dimensional Gaussian interpolation in the projector/backprojector pair of iterative reconstruction for compensation of known rigid-body motion in SPECT.
• Vitamin E inhibits melanoma growth in mice.