Greater cortical gray matter density in lithium-treated patients with bipolar disorder.

Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Research Abstract Details 

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Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Abstract Text:

BACKGROUND: The neurobiological underpinnings of bipolar disorder are not well understood. Previous neuroimaging findings have been inconsistent; however, new methods for three-dimensional (3-D) computational image analysis may better characterize neuroanatomic changes than standard volumetric measures. METHODS: We used high-resolution magnetic resonance imaging and cortical pattern matching methods to map gray matter differences in 28 adults with bipolar disorder, 70% of whom were lithium-treated (mean age = 36.1 +/- 10.5; 13 female subject), and 28 healthy control subjects (mean age = 35.9 +/- 8.5; 11 female subjects). Detailed spatial analyses of gray matter density (GMD) were conducted by measuring local proportions of gray matter at thousands of homologous cortical locations. RESULTS: Gray matter density was significantly greater in bipolar patients relative to control subjects in diffuse cortical regions. Greatest differences were found in bilateral cingulate and paralimbic cortices, brain regions critical for attentional, motivational, and emotional modulation. Secondary region of interest (ROI) analyses indicated significantly greater GMD in the right anterior cingulate among lithium-treated bipolar patients (n = 20) relative to those not taking lithium (n = 8). CONCLUSIONS: These brain maps are consistent with previous voxel-based morphometry reports of greater GMD in portions of the anterior limbic network in bipolar patients and suggest neurotrophic effects of lithium as a possible etiology of these neuroanatomic differences.

Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Publishing Authors By Initials

For similar chemical actions and uses: pharmacologic actions: physiological effects of drugs: protective agents: neuroprotective agents research abstracts see: chemical actions and uses: pharmacologic actions: physiological effects of drugs: protective agents: neuroprotective agents research

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Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Biological psychiatry

VOLUME: 62

Page Numbers: 7-16

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 19

MONTH: 01

YEAR: 2007

Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Keywords Mesh Terms:

KEYWORDS: Neuroprotective Agents

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Information

Substance Name: Neuroprotective Agents

Registry Number: 0

Grant and Affiliation Information for Greater cortical gray matter density in lithium-treated patients with bipolar disorder.

AFFILIATION: Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, California 90095, USA. cbearden@mednet.ucla.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR020571

ACRONYM: RR

MEDLINETA: Biol Psychiatry

REFSOURCE: Biol Psychiatry. 2007 Jul 1;62(1):4-6

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