Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.

Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. Research Abstract Details 

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Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. Abstract Text:

Tobias M Nowacki,Stefanie Kuerten,Wenji Zhang,Carey L Shive,Christian R Kreher,Bernhard O Boehm,Paul V Lehmann,Magdalena Tary-Lehmann,Tobias M Nowacki,Stefanie Kuerten,Wenji Zhang,Carey L Shive,Christian R Kreher,Bernhard O Boehm,Paul V Lehmann,Magdalena Tary-Lehmann,

For immune diagnostic purposes it would be critical to be able to distinguish between ongoing immune processes, such as active infections, and long-term immune memory, for example imprinted by infections that have been cleared a long time ago or by vaccinations. We tested the hypothesis that the secretion of granzyme B, as detected in ex vivo ELISPOT assays, permits this distinction. We studied EBV-, flu- and CMV-specific CD8(+) cells in healthy individuals, Vaccinia virus-reactive CD8(+) cells in the course of vaccination, and HIV-specific CD8(+) cells in HIV-infected individuals. Antigen-specific ex vivo GzB production was detected only transiently after Vaccinia immunization, and in HIV-infected individuals. Our data suggest that ex vivo ELISPOT measurements of granzyme B permit the identification of actively ongoing CD8(+) cell responses-a notion that is pertinent to the immune diagnostic of infections, transplantation, allergies, autoimmune diseases, tumors and vaccine development.

Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. Publishing Authors By Initials

TM Nowacki,S Kuerten,W Zhang,CL Shive,CR Kreher,BO Boehm,PV Lehmann,M Tary-Lehmann,TM Nowacki,S Kuerten,W Zhang,CL Shive,CR Kreher,BO Boehm,PV Lehmann,M Tary-Lehmann,

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Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cellular immunology

VOLUME: 247

Page Numbers: 36-48

Journal Abbreviation: Cell. Immunol.

ISSN: 0008-8749

DAY: 7

MONTH: 09

YEAR: 2007

Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. Information

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LANGUAGE: eng

NlmUniqueID: 1246405

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Grant and Affiliation Information for Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells.

AFFILIATION: Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.

Country: United States

AGENCY: United States NIAID

GRANT: N01-AI-40098

ACRONYM: AI

MEDLINETA: Cell Immunol

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