Gonadotropin-releasing hormone receptors.

Gonadotropin-releasing hormone receptors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Gonadotropin-releasing hormone receptors. Abstract Text:

GnRH and its analogs are used extensively for the treatment of hormone-dependent diseases and assisted reproductive techniques. They also have potential as novel contraceptives in men and women. A thorough delineation of the molecular mechanisms involved in ligand binding, receptor activation, and intracellular signal transduction is kernel to understanding disease processes and the development of specific interventions. Twenty-three structural variants of GnRH have been identified in protochordates and vertebrates. In many vertebrates, three GnRHs and three cognate receptors have been identified with distinct distributions and functions. In man, the hypothalamic GnRH regulates gonadotropin secretion through the pituitary GnRH type I receptor via activation of G(q). In-depth studies have identified amino acid residues in both the ligand and receptor involved in binding, receptor activation, and translation into intracellular signal transduction. Although the predominant coupling of the type I GnRH receptor in the gonadotrope is through productive G(q) stimulation, signal transduction can occur via other G proteins and potentially by G protein-independent means. The eventual selection of intracellular signaling may be specifically directed by variations in ligand structure. A second form of GnRH, GnRH II, conserved in all higher vertebrates, including man, is present in extrahypothalamic brain and many reproductive tissues. Its cognate receptor has been cloned from various vertebrate species, including New and Old World primates. The human gene homolog of this receptor, however, has a frame-shift and stop codon, and it appears that GnRH II signaling occurs through the type I GnRH receptor. There has been considerable plasticity in the use of different GnRHs, receptors, and signaling pathways for diverse functions. Delineation of the structural elements in GnRH and the receptor, which facilitate differential signaling, will contribute to the development of novel interventive GnRH analogs.

Gonadotropin-releasing hormone receptors. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Gonadotropin-releasing hormone receptors. Journal Published:

PUBLICATION TYPE: Review

Journal: Endocrine reviews

VOLUME: 25

Page Numbers: 235-75

Journal Abbreviation: Endocr. Rev.

ISSN: 0163-769X

DAY: 6

MONTH: Apr

YEAR: 2004

Gonadotropin-releasing hormone receptors. Information

Number of References: 297

LANGUAGE: eng

NlmUniqueID: 8006258

Gonadotropin-releasing hormone receptors. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Gonadotropin-releasing hormone receptors. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Gonadotropin-releasing hormone receptors.

AFFILIATION: Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, Chancellor's Building, 49 Little France Crescent, Edinburgh EH16 4SB, Scotland, United Kingdom. r.millar@hrsu.mrc.ac.uk

Country: United States

AGENCY: United Kingdom Medical Re

GRANT: U.1276.00.005.00002.

ACRONYM:

MEDLINETA: Endocr Rev

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Gonadotropin-releasing hormone receptors Related Publications

• A case of myositis ossificans progressiva.
• A functional outpatient desk.
• Assessment of international medical graduates and their integration into family practice: the clinician assessment for practice program.
• Caloric restriction: Impact upon pituitary function and reproduction.
• Can MR spectroscopy ever be simple and effective?
• Charcot joints in diabetic neuropathy.
• Cytoskeletal reorganization dependence of signaling by the gonadotropin-releasing hormone receptor.
• Dysplasia epiphysialis multiplex; a report of fourteen cases in three families.
• Fatigue fractures of the lower tibia; a report of five cases.
• GAVA: spectral simulation for in vivo MRS applications.
• GnRH-mediated DAN production regulates the transcription of the GnRH receptor in gonadotrope cells.
• Gonadotropin-releasing hormone receptors.
• Gonadotropin-releasing hormone-induced activation of diacylglycerol kinase-zeta and its association with active c-src.
• Henery fitzgerald MAUDSLEY.
• Improved reconstruction for MR spectroscopic imaging.
• Instillation-suction technique in chronic osteomyelitis.
• Lightning accident at Ascot.
• Proceedings: Post-operative gas gangrene managed by hyperbaric oxygen.
• Radial tunnel syndrome: resistant tennis elbow as a nerve entrapment.
• Some ideals for a psychiatric service.
• Targeting TNF-alpha receptors for neurotherapeutics.
• The management of gas gangrene with hyperbaric oxygen therapy.
• Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body.
• iTRAQ Analysis of Complex Proteome Alterations in 3xTgAD Alzheimer's Mice: Understanding the Interface between Physiology and Disease.