Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent.

Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent. Research Abstract Details 

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Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent. Abstract Text:

Paul Podsiadlo,Vladimir A Sinani,Joong Hwan Bahng,Nadine Wong Shi Kam,Jungwoo Lee,Nicholas A Kotov,Paul Podsiadlo,Vladimir A Sinani,Joong Hwan Bahng,Nadine Wong Shi Kam,Jungwoo Lee,Nicholas A Kotov,

6-Mercaptopurine and its riboside derivatives are some of the most widely utilized anti-leukemic and anti-inflammatory drugs. Their short biological half-life and severe side effects limit their use. A new delivery method for these drugs based on 4-5 nm gold nanoparticles can potentially resolve these issues. We have found substantial enhancement of the antiproliferative effect against K-562 leukemia cells of Au nanoparticles bearing 6-mercaptopurine-9-beta-d-ribofuranoside compared to the same drug in typically administered free form. The improvement was attributed to enhanced intracellular transport followed by the subsequent release in lysosomes. Enhanced activity and nanoparticle carriers will make possible the reduction of the overall concentration of the drug, renal clearance, and, thus, side effects. The nanoparticles with mercaptopurine also showed excellent stability over 1 year without loss of inhibitory activity.

Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent. Publishing Authors By Initials

P Podsiadlo,VA Sinani,JH Bahng,NW Kam,J Lee,NA Kotov,P Podsiadlo,VA Sinani,JH Bahng,NW Kam,J Lee,NA Kotov,

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Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Langmuir : the ACS journal of surfaces and colloid

VOLUME: 24

Page Numbers: 568-74

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ISSN: 0743-7463

DAY: 5

MONTH: 12

YEAR: 2007

Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent. Information

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LANGUAGE: eng

NlmUniqueID: 9882736

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Grant and Affiliation Information for Gold nanoparticles enhance the anti-leukemia action of a 6-mercaptopurine chemotherapeutic agent.

AFFILIATION: Departments of Chemical Engineering, Biomedical Engineering, and Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109.

Country: United States

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MEDLINETA: Langmuir

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