Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia.

Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia. Research Abstract Details 

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Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia. Abstract Text:

Mamoun Younes,Atilla Ertan,Gulchin Ergun,Ray Verm,Margaret Bridges,Karen Woods,Frank Meriano,A Carl Schmulen,Ronald Colman,Craig Johnson,Alberto Barroso,Jim Schwartz,John McKechnie,Juan Lechago,

CONTEXT: Identification of intestinal-type goblet cells (ITGCs) in hematoxylin-eosin-stained sections of esophageal biopsies is essential for the diagnosis of Barrett metaplasia. However, we have seen cases diagnosed as Barrett metaplasia based solely on cells that pose morphologic similarity to ITGCs on hematoxylin-eosin staining or stain positive with Alcian blue. OBJECTIVE: To determine the clinical significance of goblet cell mimickers. DESIGN: Initial biopsies from 78 patients with original diagnosis of Barrett metaplasia negative for dysplasia and a mean follow-up of 72 months were reviewed and reclassified into 3 categories: (1) ITGCs, (2) goblet cell mimickers, or (3) neither. Sections from available paraffin blocks were stained with Alcian blue at pH 2.5. The presence of the different types of cells and positive Alcian blue staining were correlated with each other and evaluated for their significance as predictors of progression to dysplasia. RESULTS: Goblet cell mimickers were present in 35 cases and were associated with ITGCs in the same biopsy in 23 (66%) of these cases. Intestinal-type goblet cells were present in 56 cases, and the remaining 10 cases, although called Barrett on the original report, did not show either ITGCs or goblet cell mimickers. Only the presence of ITGCs was associated with significant risk for dysplasia (P = .008). Positive Alcian blue staining was not associated with a significant risk for dysplasia. CONCLUSIONS: Our results indicate that the diagnosis of Barrett metaplasia should be rendered with confidence only when ITGCs are identified on routine hematoxylin-eosin-stained sections.

Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia. Publishing Authors By Initials

M Younes,A Ertan,G Ergun,R Verm,M Bridges,K Woods,F Meriano,AC Schmulen,R Colman,C Johnson,A Barroso,J Schwartz,J McKechnie,J Lechago,

For similar neoplasms: precancerous conditions research abstracts see: neoplasms: precancerous conditions research

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Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Archives of pathology & laboratory medicine

VOLUME: 131

Page Numbers: 571-5

Journal Abbreviation:

ISSN: 1543-2165

DAY: 3

MONTH: Apr

YEAR: 2007

Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia. Information

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LANGUAGE: eng

NlmUniqueID: 7607091

Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia. Keywords Mesh Terms:

KEYWORDS: Precancerous Conditions

MESH TERMS: pathology

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Grant and Affiliation Information for Goblet cell mimickers in esophageal biopsies are not associated with an increased risk for dysplasia.

AFFILIATION: Department of Pathology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA. myounes@bcm.edu

Country: United States

AGENCY: United States NCI

GRANT: R01 CA81570

ACRONYM: CA

MEDLINETA: Arch Pathol Lab Med

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