Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans.

Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Research Abstract Details 

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Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Abstract Text:

Tina L Gumienny,Lesley T MacNeil,Huang Wang,Mario de Bono,Jeffrey L Wrana,Richard W Padgett,

Bone morphogenetic protein (BMP) pathways are required for a wide variety of developmental and homeostatic decisions, and mutations in signaling components are associated with several diseases. An important aspect of BMP control is the extracellular regulation of these pathways. We show that LON-2 negatively regulates a BMP-like signaling pathway that controls body length in C. elegans. lon-2 acts genetically upstream of the BMP-like gene dbl-1, and loss of lon-2 function results in animals that are longer than normal. LON-2 is a conserved member of the glypican family of heparan sulfate proteoglycans, a family with several members known to regulate growth-factor signaling in many organisms. LON-2 is functionally conserved because the Drosophila glypican gene dally rescues the lon-2(lf) body-size defect. We show that the LON-2 protein binds BMP2 in vitro, and a mutant variation of LON-2 found in lon-2(e2140) animals diminishes this interaction. We propose that LON-2 binding to DBL-1 negatively regulates this pathway in C. elegans by attenuating ligand-receptor interactions. This is the first report of a glypican directly interacting with a growth-factor pathway in C. elegans and provides a mechanistic model for glypican regulation of growth-factor pathways.

Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Publishing Authors By Initials

TL Gumienny,LT MacNeil,H Wang,M de Bono,JL Wrana,RW Padgett,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Current biology : CB

VOLUME: 17

Page Numbers: 159-64

Journal Abbreviation: Curr. Biol.

ISSN: 0960-9822

DAY: 23

MONTH: Jan

YEAR: 2007

Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Information

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LANGUAGE: eng

NlmUniqueID: 9107782

Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: metabolism

Chemical & Substance for Abstract: Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Information

Substance Name: dally protein, Drosophila

Registry Number: 0

Grant and Affiliation Information for Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans.

AFFILIATION: Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA.

Country: England

AGENCY: United States NIA

GRANT: T32-MH/AG19957-06A2

ACRONYM: AG

MEDLINETA: Curr Biol

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