Glycosaminoglycans of cartilage and bone tissue in two cases of osteogenesis imperfecta congenita.

Glycosaminoglycans of cartilage and bone tissue in two cases of osteogenesis imperfecta congenita. Research Abstract Details 

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Glycosaminoglycans of cartilage and bone tissue in two cases of osteogenesis imperfecta congenita. Abstract Text:

B Engfeldt,A Hjerpe,

Epiphyseal cartilage and bone tissue from two cases of osteogenesis imperfecta congenita and one control case with similar skeletal age were examined regarding their glycosaminoglycan content. The diseased bone tissue showed a 3-fold increase in glycosaminoglycans, and 20-25 per cent of the chondroitin sulphate disaccharides seemed to be disulphated. The diseased cartilages showed only traces of material with characteristics of disulphates disaccharides. No disulphates disaccharides were isolated from the control materials. No difference between diseased and control material was indicated regarding molecular size, chondroitin-4-sulphate/chondroitin-6-sulphate ratio or contents of keratan sulphate and hyaluronic acid. The disease is thus associated with fundamental changes of the glycosaminoglycan structure, and these changes may be of functional importance to the mineralization process as well as to the organisation of collagen.

Glycosaminoglycans of cartilage and bone tissue in two cases of osteogenesis imperfecta congenita. Publishing Authors By Initials

B Engfeldt,A Hjerpe,

For similar organic chemicals: carboxylic acids: acids, acyclic: sugar acids: uronic acids research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: sugar acids: uronic acids research

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Glycosaminoglycans of cartilage and bone tissue in two cases of osteogenesis imperfecta congenita. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta pathologica et microbiologica Scandinavica. S

VOLUME: 84

Page Numbers: 488-94

Journal Abbreviation:

ISSN: 0365-4184

DAY: 20

MONTH: Nov

YEAR: 1976

Glycosaminoglycans of cartilage and bone tissue in two cases of osteogenesis imperfecta congenita. Information

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LANGUAGE: eng

NlmUniqueID: 7508468

Glycosaminoglycans of cartilage and bone tissue in two cases of osteogenesis imperfecta congenita. Keywords Mesh Terms:

KEYWORDS: Uronic Acids

MESH TERMS: metabolism

Chemical & Substance for Abstract: Glycosaminoglycans of cartilage and bone tissue in two cases of osteogenesis imperfecta congenita. Information

Substance Name: Chondroitin Sulfates

Registry Number: 9007-28-7

Grant and Affiliation Information for Glycosaminoglycans of cartilage and bone tissue in two cases of osteogenesis imperfecta congenita.

AFFILIATION:

Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Scand [A

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