Glycoprotein gene relocation in rabies virus.

Glycoprotein gene relocation in rabies virus. Research Abstract Details 

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Glycoprotein gene relocation in rabies virus. Abstract Text:

Xianfu Wu,Charles E Rupprecht,

Unlike vesicular stomatitis virus, rabies virus glycoprotein gene has not been successfully relocated closer to promoter-proximal regions by reverse genetics. Here we describe an efficient system for the Evelyn-Rokitnicki-Abelseth (ERA) rabies virus with the glycoprotein gene switched with the matrix protein gene, creating a reshuffled virus ERAgm (gene order N-P-G-M-L). With the aid of an autogene plasmid, the T7 RNA polymerase containing a nuclear location signal from the SV40 large T antigen facilitated virus recovery. The rearranged ERAgm rabies virus replicated as well as the parental ERA (gene order N-P-M-G-L) virus, reaching 10(9)ffu/ml in infected BSR cells. The altered glycoprotein gene position in viral genome presented an alternative way to study the pathogenicity of rabies virus. This also provides a potential novel method for rabies vaccine development.

Glycoprotein gene relocation in rabies virus. Publishing Authors By Initials

X Wu,CE Rupprecht,

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Glycoprotein gene relocation in rabies virus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virus research

VOLUME: 131

Page Numbers: 95-9

Journal Abbreviation: Virus Res.

ISSN: 0168-1702

DAY: 11

MONTH: 09

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 8410979

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Grant and Affiliation Information for Glycoprotein gene relocation in rabies virus.

AFFILIATION: Centers for Disease Control and Prevention, Rabies Program/PRB /DVRD/CDC, Building 17, Room 6045, MS-G33, 1600 Clifton Road, Atlanta, GA 30333, USA.

Country: Netherlands

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MEDLINETA: Virus Res

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