Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs.

Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs. Research Abstract Details 

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Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs. Abstract Text:

Nadya Morozova,Konstantin Khrapko,Jun Panee,Wanyu Liu,John W Harney,Marla J Berry,

Glutathione plays an essential role in maintaining cellular redox balance, protecting cells from oxidative stress and detoxifying xenobiotic compounds. Glutathione depletion has been implicated in neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. Cells of neuronal origin are acutely sensitive to glutathione depletion, providing an avenue for studying the mechanisms invoked for neuronal survival in response to oxidant challenge. We investigated the changes in mRNA profile in HT22 hippocampal cells following administration of homocysteic acid (HCA), a glutathione-depleting drug. We report that HCA treatment of HT22 murine hippocampal cells increases the levels of the mRNAs encoding at least three proteins involved in protection from oxidant injury, the mRNAs encoding heavy (H) and light (L) ferritin and glutathione S-transferase (GST).

Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs. Publishing Authors By Initials

N Morozova,K Khrapko,J Panee,W Liu,JW Harney,MJ Berry,

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Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genes to cells : devoted to molecular & cellular m

VOLUME: 12

Page Numbers: 561-7

Journal Abbreviation: Genes Cells

ISSN: 1356-9597

DAY: 3

MONTH: May

YEAR: 2007

Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs. Information

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LANGUAGE: eng

NlmUniqueID: 9607379

Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs. Keywords Mesh Terms:

KEYWORDS: Reverse Transcriptase Polymerase Chain R

MESH TERMS: metabolism

Chemical & Substance for Abstract: Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs. Information

Substance Name: Glutathione Transferase

Registry Number: EC 2.5.1.18

Grant and Affiliation Information for Glutathione depletion in hippocampal cells increases levels of H and L ferritin and glutathione S-transferase mRNAs.

AFFILIATION: Thyroid Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. morozova@uic.edu

Country: England

AGENCY: United States NINDS

GRANT: NS40302

ACRONYM: NS

MEDLINETA: Genes Cells

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