Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat.

Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Research Abstract Details 

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Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Abstract Text:

Lou Ann S Brown,Xiao-Du Ping,Frank L Harris,Theresa W Gauthier,

We have previously demonstrated that chronic alcohol exposure decreases glutathione in the alveolar space. Although alcohol use is associated with decreased alveolar macrophage function, the mechanism by which alcohol impairs macrophage phagocytosis is unknown. In the current study, we examined the possibility that ethanol-induced alveolar macrophage dysfunction was secondary to decreased glutathione and subsequent chronic oxidative stress in the alveolar space. After 6 wk of ethanol ingestion, oxidant stress in the alveolar macrophages was evidenced by a 30-mV oxidation of the GSH/GSSG redox potential (P

Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Publishing Authors By Initials

LA Brown,XD Ping,FL Harris,TW Gauthier,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Lung cellular and

VOLUME: 292

Page Numbers: L824-32

Journal Abbreviation:

ISSN: 1040-0605

DAY: 22

MONTH: 11

YEAR: 2006

Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901229

Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: metabolism

Chemical & Substance for Abstract: Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat. Information

Substance Name: Poly(ADP-ribose) Polymerases

Registry Number: EC 2.4.2.30

Grant and Affiliation Information for Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat.

AFFILIATION: Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. lbrow03@emory.edu

Country: United States

AGENCY: United States NICHD

GRANT: R03 HD-39651

ACRONYM: HD

MEDLINETA: Am J Physiol Lung Cell Mol Phy

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