Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging.

Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Abstract Text:

We investigated regional variations and the effects of aging on the expression of the N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazole (AMPA) receptor subunits in several memory-associated structures using Western blotting. In young adult rats, NR1, NR2A, and GluR2 levels varied between the hippocampus and parahippocampal region and between the subregions of the hippocampus. When a comparison was made between young (4-month-old) and aged (24-month-old) rats, significant decreases in NR1 expression were found in the aged ventral hippocampus and the entorhinal and postrhinal cortices. There were significant decreases in NR2A expression in the aged parahippocampal region, but not in the hippocampus. The expression of the GluR2 subunit was significantly reduced in the ventral hippocampus and the postrhinal cortex. A dramatic decrease in NR1 and GluR2 expression was found in the aged CA2/3 and CA1, respectively, but there were no significant age-related changes in NR2A expression. All three subunits were expressed at a similar level in the two age groups in the prefrontal cortex. These results suggest differential expression and effects of aging on NMDA and AMPA receptor subunits in memory-associated brain structures. Synapse 62:834-841, 2008. (c) 2008 Wiley-Liss, Inc.

Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Synapse (New York, N.Y.)

VOLUME: 62

Page Numbers: 834-41

Journal Abbreviation: Synapse

ISSN: 1098-2396

DAY: 15

MONTH: Nov

YEAR: 2008

Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8806914

Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging.

AFFILIATION: Department of Anatomy and Structural Biology, School of Medical Sciences, University of Otago, Dunedin, New Zealand.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Synapse

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging Related Publications

• Adenosine and cytokine levels following treatment of rheumatoid arthritis with dipyridamole.
• Alterations in xenobiotic metabolism in the long-lived Little mice.
• Blood and speech.
• Comparative field performance over 3 years and two sites of transgenic wheat lines expressing HMW subunit transgenes.
• Cytosolic glucocorticoid receptor expression in the rat vestibular nucleus and hippocampus following unilateral vestibular deafferentation.
• Effects of intra-vestibular nucleus injection of the group I metabotropic glutamate receptor antagonist AIDA on vestibular compensation in guinea pigs.
• Genetic particles.
• Glutamate receptor subunits expression in memory-associated brain structures: Regional variations and effects of aging.
• Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin.
• Lymphoid neogenesis and immune infiltration in aged liver.
• MBP-8298, a synthetic peptide analog of myelin basic protein for the treatment of multiple sclerosis.
• Medical history, sexual, and maturational factors and prostate cancer risk.
• Oral tumors.
• Osteonecrosis at multiple sites in a patient with systemic lupus erythematosus.
• Overview of research on health-related quality of life in patients with chronic liver disease.
• Quantitative changes in gene expression of glutamate receptor subunits/subtypes in the vestibular nucleus, inferior olive and flocculus before and following unilateral labyrinthectomy in the rat: real-time quantitative PCR method.
• Reproductive versatility in Rubus; raspberry-blackberry hybrids; on an integrated species difference.
• The changing face of insulin receptors.
• The contribution of nitric oxide to vestibular compensation: are there species differences?
• The effect of delta 9-tetrahydrocannabinol on the extinction of an adverse associative memory.
• The geographical distribution of cold-blooded vertebrates.
• The geographical distribution of cold-blooded vertebrates.
• The plasmagene theory of the origin of cancer.
• The transcription factor HNF1 acts with C/EBP alpha to synergistically activate the human albumin promoter through a novel domain.
• Threat of disease in tropical crops.
• Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers.
• Tryptophan, adenosine, neurodegeneration and neuroprotection.