Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus.

Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus. Research Abstract Details 

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Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus. Abstract Text:

Yuto Ueda,Hidekatsu Yokoyama,Akira Nakajima,Jun Tokumaru,Taku Doi,Yoshio Mitsuyama,

Kainic acid (KA) induces seizures and degeneration in CA1 of the ventral hippocampus, though its mechanism of action is unknown. We used KA to induce seizures in freely moving rats prepared for in vivo microdialysis with probe placement, and then measured extracellular glutamate with an online fluorometric detector. Generation of free radicals was monitored by electron paramagnetic resonance (EPR) spectroscopy coupled with perfusion of the spin-trapping agent, alpha-(4-pyridyl- N-oxide)- N- tert-butylnitrone (POBN). Regional antioxidant efficacy was measured by observing the eliminating ratio of nitroxide radicals, using 3-carbamoyl-2, 2, 5, 5-tetramethylpyrrolidine-1-oxyl (carbamoyl-PROXYL) applied exogenously from the probe. Increased levels of extracellular glutamate observed at the initiation of KA-induced seizures appear to be associated with generation of lipid free radicals and with a decrease in residual antioxidant effects. These data suggest that collapse of the redox state in the hippocampus, the region most vulnerable to injury from seizure activity, may be critical in the regional injury induced by seizures. Further, we propose that the functional failure of glutamate transporters due to oxidative stress results in high levels of extracellular glutamate during sustained generalized seizures induced with KA.

Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus. Publishing Authors By Initials

Y Ueda,H Yokoyama,A Nakajima,J Tokumaru,T Doi,Y Mitsuyama,

For similar nervous system diseases: central nervous system diseases: brain diseases: epilepsy: status epilepticus research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: epilepsy: status epilepticus research

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Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 147

Page Numbers: 219-26

Journal Abbreviation:

ISSN: 0014-4819

DAY: 25

MONTH: 09

YEAR: 2002

Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus. Keywords Mesh Terms:

KEYWORDS: Status Epilepticus

MESH TERMS: metabolism

Chemical & Substance for Abstract: Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus. Information

Substance Name: Glutamic Acid

Registry Number: 56-86-0

Grant and Affiliation Information for Glutamate excess and free radical formation during and following kainic acid-induced status epilepticus.

AFFILIATION: Department of Psychiatry, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. usan@post1.miyazaki-med.ac.jp

Country: Germany

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MEDLINETA: Exp Brain Res

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