Glucose partition coefficient and diffusivity in the lower skin layers.

Glucose partition coefficient and diffusivity in the lower skin layers. Research Abstract Details 

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Glucose partition coefficient and diffusivity in the lower skin layers. Abstract Text:

Enam Khalil,Kosmas Kretsos,Gerald B Kasting,

PURPOSE: This work aims to estimate the diffusivity and partitioning of glucose in the dermis and the viable epidermis of human skin. METHODS: The partition coefficient of glucose between phosphate-buffered saline and dermis, tape-stripped epidermis (TSE), stratum corneum (SC), and split-thickness skin, was measured in vitro using human cadaver skin. Glucose permeability across dermis and tape-stripped split-thickness skin (TSS) was measured using side-by-side diffusion cells. Glucose desorption from TSE and human epidermal membrane (HEM) was measured. All measurements were conducted at 32 degrees C. RESULTS: The partition coefficient for glucose [mean +/- SD (no. of samples)] was 0.65 +/- 0.09 (n = 25) for dermis, 0.81 +/- 0.06 (n = 10) for TSE, and 0.53 +/- 0.12 (n = 9) for SC. Glucose diffusivity in dermis was calculated to be 2.64 +/- 0.42 x 10(-6) cm2/s (n = 14). Glucose diffusivities in the viable epidermis estimated from TSS permeation, TSE desorption, and HEM desorption were 0.075 +/- 0.050 x 10(-6) cm2/s (n = 5), 0.037 +/- 0.018 x 10(-6) cm2/s (n = 4), and 1.0 +/- 0.6 x 10(-6) cm2/s (n = 4), respectively. CONCLUSION: The tissue/buffer partition coefficient of glucose in all skin layers was found to be less than unity, suggestive of excluded volumes in each layer. Glucose diffusivity in human dermis was found to be one third of its value in water, indicative of hindered diffusion related to the structural components of the tissue. A substantially lower value for glucose diffusivity in viable epidermis is suggested.

Glucose partition coefficient and diffusivity in the lower skin layers. Publishing Authors By Initials

E Khalil,K Kretsos,GB Kasting,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Glucose partition coefficient and diffusivity in the lower skin layers. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Pharmaceutical research

VOLUME: 23

Page Numbers: 1227-34

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 26

MONTH: 05

YEAR: 2006

Glucose partition coefficient and diffusivity in the lower skin layers. Information

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LANGUAGE: eng

NlmUniqueID: 8406521

Glucose partition coefficient and diffusivity in the lower skin layers. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Glucose partition coefficient and diffusivity in the lower skin layers. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for Glucose partition coefficient and diffusivity in the lower skin layers.

AFFILIATION: Faculty of Pharmacy, The University of Jordan, Amman, 11942, Jordan. ekayoub@ju.edu.jo

Country: United States

AGENCY: United States NIOSH

GRANT: R01 OH07529

ACRONYM: OH

MEDLINETA: Pharm Res

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