Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease.

Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease. Research Abstract Details 

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Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease. Abstract Text:

Stasia S Reynolds,Lisa R Yanek,Dhananjay Vaidya,Samia Mora,Taryn F Moy,Christopher D Saudek,Lewis C Becker,Diane M Becker,

PURPOSE: Little is known about excess risk of incident diabetes conferred by fasting plasma glucose (FPG) within the normal range (<5.6 mmol/l) for high risk families. METHODS: Healthy 30-59 year old non-diabetic siblings (N = 542) of index cases with documented premature coronary disease were followed prospectively for type 2 diabetes. RESULTS: During 8.7+/-3 years of follow-up, incident diabetes was identified in 7.8%. Rates were incremental with baseline non-diabetes FPG thresholds of 5.0, 5.6, 6.1, and 6.7 mmol/l (p for trend < 0.0001). FPG was the strongest predictor of incident diabetes even across levels within the normal range. The multivariable adjusted relative risk was 14.9 (95% CI = 3.4-65.2) at FPG thresholds > or =5.0 mmol/l versus FPG <5.0 mmol/l. The maximal diagnostic efficiency for FPG was 5.50 mmol/l; with sensitivity and specificity 0.782. All FPG thresholds in the normal range between 5.0 and 5.6 mmol/l showed efficiency levels >0.74. The overall area under the ROC curve predicting incident diabetes for normal and prediabetes ranges of FPG was 0.867. CONCLUSION: Higher FPG levels within the designated "normal" range in high risk families are a potent independent risk factor for type 2 diabetes and may serve as a sentinel to trigger primary preventive interventions.

Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease. Publishing Authors By Initials

SS Reynolds,LR Yanek,D Vaidya,S Mora,TF Moy,CD Saudek,LC Becker,DM Becker,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Diabetes research and clinical practice

VOLUME: 74

Page Numbers: 267-73

Journal Abbreviation: Diabetes Res. Clin. Pract.

ISSN: 0168-8227

DAY: 23

MONTH: 05

YEAR: 2006

Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease. Information

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LANGUAGE: eng

NlmUniqueID: 8508335

Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease. Information

Substance Name: Blood Glucose

Registry Number: 0

Grant and Affiliation Information for Glucose levels in the normal range predict incident diabetes in families with premature coronary heart disease.

AFFILIATION: Divisions of General Internal Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Country: Ireland

AGENCY: United States NHLBI

GRANT: R18 HL58625

ACRONYM: HL

MEDLINETA: Diabetes Res Clin Pract

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