Glucocorticoids and the osteoclast.

Glucocorticoids and the osteoclast. Research Abstract Details 

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Glucocorticoids and the osteoclast. Abstract Text:

Hyun-Ju Kim,Haibo Zhao,Hideki Kitaura,Sandip Bhattacharyya,Judson A Brewer,Louis J Muglia,F Patrick Ross,Steven L Teitelbaum,Hyun-Ju Kim,Haibo Zhao,Hideki Kitaura,Sandip Bhattacharyya,Judson A Brewer,Louis J Muglia,F Patrick Ross,Steven L Teitelbaum,Hyun-Ju Kim,Haibo Zhao,Hideki Kitaura,Sandip Bhattacharyya,Judson A Brewer,Louis J Muglia,F Patrick Ross,Steven L Teitelbaum,

Glucocorticoid (GC)-induced bone loss is the most common cause of secondary osteoporosis but its pathogenesis is controversial. GCs clearly suppress bone formation in vivo but the means by which they impact osteoblasts is unclear. Because bone remodeling is characterized by tethering of the activities of the two cells, the osteoclast is a potential modulator of the effect of GCs on osteoblasts. To address this issue we compared the effects of dexamethasone on wild-type (WT) osteoclasts with those derived from mice with disruption of the GC receptor in osteoclast lineage cells and found that the bone-degrading capacity of GC-treated WT cells is suppressed. The inhibitory effect of dexamethasone on bone resorption reflects failure of osteoclasts to organize their cytoskeleton in response to M-CSF. Dexamethasone specifically arrests M-CSF activation of RhoA, Rac, and Vav3, each of which regulate the osteoclast cytoskeleton. In all circumstances, mice lacking the GC receptor in osteoclast lineage cells are spared the impact of dexamethasone on osteoclasts and their precursors. Consistent with osteoclasts modulating the osteoblast-suppressive effect of dexamethasone, GC receptor-deficient mice are protected from the steroid's inhibition of bone formation.

Glucocorticoids and the osteoclast. Publishing Authors By Initials

HJ Kim,H Zhao,H Kitaura,S Bhattacharyya,JA Brewer,LJ Muglia,F Patrick Ross,SL Teitelbaum,HJ Kim,H Zhao,H Kitaura,S Bhattacharyya,JA Brewer,LJ Muglia,F Patrick Ross,SL Teitelbaum,HJ Kim,H Zhao,H Kitaura,S Bhattacharyya,JA Brewer,LJ Muglia,F Patrick Ross,SL Teitelbaum,

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Glucocorticoids and the osteoclast. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of the New York Academy of Sciences

VOLUME: 1116

Page Numbers: 335-9

Journal Abbreviation: Ann. N. Y. Acad. Sci.

ISSN: 0077-8923

DAY: 17

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Glucocorticoids and the osteoclast.

AFFILIATION: Washington University School of Medicine, Department of Pathology and Immunology, Campus Box 8118, 660 South Euclid Avenue, St. Louis, MO 63110. teitelbs@wustl.edu.

Country: United States

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MEDLINETA: Ann N Y Acad Sci

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