Glucocorticoid influences on the auditory brain-stem responses in man.

Glucocorticoid influences on the auditory brain-stem responses in man. Research Abstract Details 

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Glucocorticoid influences on the auditory brain-stem responses in man. Abstract Text:

The present study was designed to test whether human auditory brain-stem responses (ABRs) are sensitive to peripheral endocrine signals as reflected by changes in the plasma glucocorticoid concentration. ABRs were recorded following treatment with 50 mg hydrocortisone or placebo in 13 healthy male adults. Experiments were double-blind and designed according to a latin-square within-subject comparison. Treatment was applied 1 h prior to testing as an i.v. infusion over a period of 20 min. Subjects were tested in each session under 3 X 3 conditions, i.e., ABRs were obtained to series of clicks presented at 3 different intensities (80, 60, 40 dB HL) and with 3 different stimulus rates (39, 10, 5 clicks/sec). Additionally, oral temperature was monitored. Hydrocortisone significantly reduced latencies of waves III, V, and VI (and subsequent negative troughs) when low stimulus intensities were used. Furthermore, the glucocorticoid reduced latencies of waves Vn, VI and VIn when the clicks were presented at a slow stimulus rate. Further studies have to specify the underlying mechanisms of these changes.

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Glucocorticoid influences on the auditory brain-stem responses in man. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Electroencephalography and clinical neurophysiolog

VOLUME: 74

Page Numbers: 209-16

Journal Abbreviation: Electroencephalogr Clin Neurop

ISSN: 0013-4694

DAY: 9

MONTH: 09

YEAR: 2008

Glucocorticoid influences on the auditory brain-stem responses in man. Information

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LANGUAGE: eng

NlmUniqueID: 375035

Glucocorticoid influences on the auditory brain-stem responses in man. Keywords Mesh Terms:

KEYWORDS: Reference Values

MESH TERMS: drug effects

Chemical & Substance for Abstract: Glucocorticoid influences on the auditory brain-stem responses in man. Information

Substance Name: Hydrocortisone

Registry Number: 50-23-7

Grant and Affiliation Information for Glucocorticoid influences on the auditory brain-stem responses in man.

AFFILIATION: Department of Applied Physiology, University of Ulm, F.R.G.

Country: IRELAND

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MEDLINETA: Electroencephalogr Clin Neurop

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