Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes.

Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes. Research Abstract Details 

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Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes. Abstract Text:

Vikas Misra,Hannah Lee,Anju Singh,Kewu Huang,Rajesh K Thimmulappa,Wayne Mitzner,Shyam Biswal,Clarke G Tankersley,Vikas Misra,Hannah Lee,Anju Singh,Kewu Huang,Rajesh K Thimmulappa,Wayne Mitzner,Shyam Biswal,Clarke G Tankersley,Vikas Misra,Hannah Lee,Anju Singh,Kewu Huang,Rajesh K Thimmulappa,Wayne Mitzner,Shyam Biswal,Clarke G Tankersley,

This study identified gene expression profiles that provided evidence for genomic mechanisms underlying the pathophysiology of aging lung. Aging lungs from C57BL/6 (B6) and DBA/2 (D2) mouse strains differ in physiology and morphometry. Lungs were harvested from B6 mice at 2, 18, and 26 mo and from D2 mice at 2 and 18 mo of age. Purified RNA was subjected to oligonucleotide microarray analyses, and differential expression analyses were performed for comparison of various data sets. A significant majority of differentially expressed genes were upregulated with aging in both strains. Aging D2 lungs uniquely exhibited upregulation in stress-response genes including xenobiotic detoxification cascades. In contrast, aging B6 lungs showed downregulation of heat shock-response genes. Age-dependent downregulation of genes common to both B6 and D2 strains included several collagen genes (e.g., Col1a1 and Col3a1). There was a greater elastin gene (Eln) expression in D2 mice at 2 mo, and Eln was uniquely downregulated with age in this strain. The matrix metalloproteinase 14 gene (Mmp14), critical to alveolar structural integrity, was also downregulated with aging in D2 mice only. Several polymorphisms in the regulatory and untranslated regions of Mmp14 were identified between strains, suggesting that variation in Mmp14 gene regulation contributes to accelerated aging of lungs in D2 mice. In summary, lungs of B6 and D2 mice age with variable rates at the gene expression level, and these quantifiable genomic differences provide a template for understanding the variability in age-dependent changes in lung structure and function.

Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes. Publishing Authors By Initials

V Misra,H Lee,A Singh,K Huang,RK Thimmulappa,W Mitzner,S Biswal,CG Tankersley,V Misra,H Lee,A Singh,K Huang,RK Thimmulappa,W Mitzner,S Biswal,CG Tankersley,V Misra,H Lee,A Singh,K Huang,RK Thimmulappa,W Mitzner,S Biswal,CG Tankersley,

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Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Physiological genomics

VOLUME: 31

Page Numbers: 429-40

Journal Abbreviation: Physiol. Genomics

ISSN: 1531-2267

DAY: 28

MONTH: 08

YEAR: 2007

Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes. Information

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LANGUAGE: eng

NlmUniqueID: 9815683

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Grant and Affiliation Information for Global expression profiles from C57BL/6J and DBA/2J mouse lungs to determine aging-related genes.

AFFILIATION: Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: P30-ES-038819

ACRONYM: ES

MEDLINETA: Physiol Genomics

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