GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence.

GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Abstract Text:

Jin Woo Bok,DaWoon Chung,S Arunmozhi Balajee,Kieren A Marr,David Andes,Kristian Fog Nielsen,Jens C Frisvad,Katharine A Kirby,Nancy P Keller,

Gliotoxin is a nonribosomal peptide produced by Aspergillus fumigatus. This compound has been proposed as an A. fumigatus virulence factor due to its cytotoxic, genotoxic, and apoptotic properties. Recent identification of the gliotoxin gene cluster identified several genes (gli genes) likely involved in gliotoxin production, including gliZ, encoding a putative Zn(2)Cys(6) binuclear transcription factor. Replacement of gliZ with a marker gene (DeltagliZ) resulted in no detectable gliotoxin production and loss of gene expression of other gli cluster genes. Placement of multiple copies of gliZ in the genome increased gliotoxin production. Using endpoint survival data, the DeltagliZ and a multiple-copy gliZ strain were not statistically different from the wild type in a murine pulmonary model; however, both the wild-type and the multiple-copy gliZ strain were more virulent than DeltalaeA (a mutant reduced in production of gliotoxin and other toxins). A flow-cytometric analysis of polymorphonuclear leukocytes (PMNs) exposed to supernatants from wild-type, DeltagliZ, complemented DeltagliZ, and DeltalaeA strains supported a role for gliotoxin in apoptotic but not necrotic PMN cell death. This may indicate that several secondary metabolites are involved in A. fumigatus virulence.

GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Publishing Authors By Initials

JW Bok,D Chung,SA Balajee,KA Marr,D Andes,KF Nielsen,JC Frisvad,KA Kirby,NP Keller,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: virulence research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: virulence research

PUBMED ID PMID:

MEDLINE DATE:

GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Infection and immunity

VOLUME: 74

Page Numbers: 6761-8

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 9

MONTH: 10

YEAR: 2006

GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 246127

GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Keywords Mesh Terms:

KEYWORDS: Virulence

MESH TERMS: genetics

Chemical & Substance for Abstract: GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence. Information

Substance Name: Gliotoxin

Registry Number: 67-99-2

Grant and Affiliation Information for GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence.

AFFILIATION: Department of Plant Pathology, University of Wisconsin-Madison, 882 Russell Labs, 1630 Linden Drive, Madison, WI 53706, USA.

Country: United States

AGENCY: United States NIAID

GRANT: R01 AI 051468

ACRONYM: AI

MEDLINETA: Infect Immun

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence Related Publications

• A 3D model of Reelin subrepeat regions predicts Reelin binding to carbohydrates.
• Age-related alterations of Apolipoprotein E and interleukin-1beta in the aging brain.
• Antenatal and postnatal lung and vascular anatomic and functional studies in congenital diaphragmatic hernia: implications for clinical management.
• BMP-4 is required for hepatic specification of mouse embryonic stem cell-derived definitive endoderm.
• Bone morphogenetic protein 2 induces placental growth factor in mesenchymal stem cells.
• Candicine from Stapelia gigantea.
• Children's skin conductance reactivity as a mechanism of risk in the context of parental depressive symptoms.
• Comparison of extracellular and intracellular potency of botulinum neurotoxins.
• Cystic fibrosis transmembrane conductance regulator (CFTR) functionality is dependent on coatomer protein I (COPI).
• Development of the hemangioblast defines the onset of hematopoiesis in human ES cell differentiation cultures.
• Drosophila melanogaster's history as a human commensal.
• Effect of glucocorticoid-induced osteoporotic-like conditions on osteoblast cell attachment to implant surface microtopographies.
• Effect of operational parameters on the recovery rate of an oleophilic drum skimmer.
• Flagellar elongation and gene expression in Chlamydomonas reinhardtii.
• GliZ, a transcriptional regulator of gliotoxin biosynthesis, contributes to Aspergillus fumigatus virulence.
• Illegitimate recombination is a major evolutionary mechanism for initiating size variation in plant resistance genes.
• Interplay between oxidative damage, protein synthesis, and protein degradation in Alzheimer's disease.
• Metabolic pathway engineering in cotton: Biosynthesis of polyhydroxybutyrate in fiber cells.
• Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages.
• Production of targeted poly(3-hydroxyalkanoates) copolymers by glycogen accumulating organisms using acetate as sole carbon source.
• Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness.
• Reproductive isolation between Pogonomyrmex rugosus and two lineages with genetic caste determination.
• Secondary metabolic gene cluster silencing in Aspergillus nidulans.
• Short telomeres in short-lived males: what are the molecular and evolutionary causes?
• The presumptive floor plate (notoplate) induces behaviors associated with convergent extension in medial but not lateral neural plate cells of Xenopus.
• The role of Wnts in bone metastases.
• The whisking rhythm generator: a novel mammalian network for the generation of movement.
• Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA.
• What impact, if any, has feminism had on science?
• [Extraction of thermolabile compounds with supercritical gases.]