Glioblastoma.

Glioblastoma. Research Abstract Details 

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Glioblastoma. Abstract Text:

C Ryan Miller,Arie Perry,

CONTEXT: Glioblastoma (GBM), the most common primary intracranial malignancy, is a morphologically diverse neoplasm with dismal prognosis despite multimodality therapy. Only 3 distinct morphologic variants of GBM are currently recognized by the current World Health Organization classification scheme, including GBM, giant cell GBM, and gliosarcoma. Additional variants, some of which have significant morphologic overlap with tumors that have more favorable prognosis and treatment response rates, particularly anaplastic oligodendroglioma, have been described since its publication in 2000 and may be included in the next classification. OBJECTIVE: To summarize the morphologic and molecular genetic diversity of both well-established and novel GBM variants and outline our approach to these heterogeneous neoplasms and their distinction from other diffuse, high-grade gliomas. DATA SOURCES: Published literature and our own experience in an active academic diagnostic surgical neuropathology practice were reviewed. CONCLUSIONS: Precise subclassification of GBM is required for accurate prognostication and appropriate treatment planning.

Glioblastoma. Publishing Authors By Initials

CR Miller,A Perry,

For similar neoplasms: neoplasms by histologic type: neoplasms, germ cell and embryonal: neuroectodermal tumors: neoplasms, neuroepithelial: glioma: oligodendroglioma research abstracts see: neoplasms: neoplasms by histologic type: neoplasms, germ cell and embryonal: neuroectodermal tumors: neoplasms, neuroepithelial: glioma: oligodendroglioma research

PUBMED ID PMID:

MEDLINE DATE:

Glioblastoma. Journal Published:

PUBLICATION TYPE: Review

Journal: Archives of pathology & laboratory medicine

VOLUME: 131

Page Numbers: 397-406

Journal Abbreviation: Arch. Pathol. Lab. Med.

ISSN: 1543-2165

DAY: 3

MONTH: Mar

YEAR: 2007

Glioblastoma. Information

Number of References: 58

LANGUAGE: eng

NlmUniqueID: 7607091

Glioblastoma. Keywords Mesh Terms:

KEYWORDS: Oligodendroglioma

MESH TERMS: pathology

Chemical & Substance for Abstract: Glioblastoma. Information

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Grant and Affiliation Information for Glioblastoma.

AFFILIATION: Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA.

Country: United States

AGENCY: United States NCI

GRANT: T32CA009547

ACRONYM: CA

MEDLINETA: Arch Pathol Lab Med

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