Glial progenitor-based repair of demyelinating neurological diseases.

Glial progenitor-based repair of demyelinating neurological diseases. Research Abstract Details 

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Glial progenitor-based repair of demyelinating neurological diseases. Abstract Text:

H Michael Keyoung,Steven A Goldman,

Demyelinating diseases of the brain and spinal cord affect more than one-quarter million of Americans, with numbers reaching more than two million across the world. These patients experience not only the vascular, traumatic, and inflammatory demyelinations of adulthood but the congenital and childhood dysmyelinating syndromes of the pediatric leukodystrophies. Several disease-modifying strategies have been developed that slow disease progression, especially in the inflammatory demyelinations and in multiple sclerosis in particular. Yet, currently available disease modifiers typically influence the immune system and are neither intended to nor competent to reverse the structural neurologic damage attending acquired demyelination. Fortunately, however, the disorders of myelin lend themselves well to attempts at structural repair, because central oligodendrocytes are the primary, and often sole, victims of the underlying disease process. Given the relative availability and homogeneity of human oligodendrocyte progenitor cells, the disorders of myelin formation and maintenance may be especially compelling targets for cell-based neurologic therapy.

Glial progenitor-based repair of demyelinating neurological diseases. Publishing Authors By Initials

HM Keyoung,SA Goldman,

For similar surgical procedures, operative: transplantation: cell transplantation: stem cell transplantation research abstracts see: surgical procedures, operative: transplantation: cell transplantation: stem cell transplantation research

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Glial progenitor-based repair of demyelinating neurological diseases. Journal Published:

PUBLICATION TYPE: Review

Journal: Neurosurgery clinics of North America

VOLUME: 18

Page Numbers: 93-104, x

Journal Abbreviation: Neurosurg. Clin. N. Am.

ISSN: 1042-3680

DAY: 3

MONTH: Jan

YEAR: 2007

Glial progenitor-based repair of demyelinating neurological diseases. Information

Number of References: 63

LANGUAGE: eng

NlmUniqueID: 9008004

Glial progenitor-based repair of demyelinating neurological diseases. Keywords Mesh Terms:

KEYWORDS: Stem Cell Transplantation

MESH TERMS: trends

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Grant and Affiliation Information for Glial progenitor-based repair of demyelinating neurological diseases.

AFFILIATION: Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, PO Box 0470, San Francisco, CA 94143-0470, USA. keyoungh@neurosurg.ucsf.edu

Country: United States

AGENCY: United States NINDS

GRANT: NS39559

ACRONYM: NS

MEDLINETA: Neurosurg Clin N Am

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