Glial cells more than support cells?

Glial cells more than support cells? Research Abstract Details

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Glial cells more than support cells? Abstract Text:

Fei He,Yi E Sun,

Glial cells are the most abundant cells in the human brain and have long been considered as passive supporting cells for neurons. In contrast to the extensive studies on various neuronal functions in the nervous system, we still have limited knowledge about glial cells. Recently a number of pioneering studies have provided convincing evidence that glia play active roles in development and function of the central nervous system. This review discusses recent advances in our understanding of the molecular mechanisms underlying glial cell differentiation. We then highlight some of the novel findings about glial function, i.e. the role of glia in synaptogenesis and the intricate relationship between astrocytes and adult neural stem cells. Finally, we summarize the emerging studies that implicate abnormalities in the formation or maintenance of glia leading to severe brain diseases, such as Alexander disease, glioblastoma and multiple sclerosis, and potential therapeutic strategies to tackle these diseases.

Glial cells more than support cells? Publishing Authors By Initials

F He,YE Sun,

For similar nervous system: synapses research abstracts see: nervous system: synapses research

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Glial cells more than support cells? Journal Published:

PUBLICATION TYPE: Review

Journal: The international journal of biochemistry & cell b

VOLUME: 39

Page Numbers: 661-5

Journal Abbreviation: Int. J. Biochem. Cell Biol.

ISSN: 1357-2725

DAY: 2

MONTH: 11

YEAR: 2006

Glial cells more than support cells? Information

Number of References: 20

LANGUAGE: eng

NlmUniqueID: 9508482

Glial cells more than support cells? Keywords Mesh Terms:

KEYWORDS: Synapses

MESH TERMS: physiology

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Grant and Affiliation Information for Glial cells more than support cells?

AFFILIATION: Department of Molecular & Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, USA. fhe@mednet.ucla.edu

Country: England