Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity.

Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. Abstract Text:

Zhu Li,Ke Ya,Wu Xiao-Mei,Yang Lei,Lu Yang,Qian Zhong Ming,Zhu Li,Ke Ya,Wu Xiao-Mei,Yang Lei,Lu Yang,Qian Zhong Ming,

We hypothesized that the neuroprotective role of the standardized Ginkgo biloba (Ginkgoaceae) extract EGb 761 under hypoxic conditions might be associated with its function to increase HIF-1 activity based on the fact that oxygen availability is crucial for cellular metabolism and viability and that HIF-1 plays an essential role in cellular oxygen homeostasis under hypoxic conditions. In this study, we therefore investigated the effects of ginkgolides, the main constituent of the non-flavone fraction of EGb 761, on the content and activity of HIF-1alpha, a key factor to determine HIF-1 activity, in hypoxic PC12 cells induced by cobalt chloride. Our data demonstrated that ginkgolides have a significant protective role against hypoxia-induced injury in the PC12 cells. The findings also strongly support our hypothesis that the protective role of ginkgolides is due to the up-regulation of HIF-1alpha protein expression and modification through the ginkgolides-induced activation of the p42/p44 MAPK pathway. In addition, it was evident that ginkgolides could significantly increase the HIF-1 DNA binding activity, which might also be associated with the protective effects of ginkgolides by promoting the expression of target genes of HIF-1 under hypoxic conditions. J. Cell. Biochem. 103: 564-575, 2008. (c) 2007 Wiley-Liss, Inc.

Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. Publishing Authors By Initials

Z Li,K Ya,W Xiao-Mei,Y Lei,L Yang,QZ Ming,Z Li,K Ya,W Xiao-Mei,Y Lei,L Yang,QZ Ming,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cellular biochemistry

VOLUME: 103

Page Numbers: 564-75

Journal Abbreviation: J. Cell. Biochem.

ISSN: 0730-2312

DAY: 1

MONTH: Feb

YEAR: 2008

Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8205768

Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity.

AFFILIATION: Institute for Nautical Medicine and Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, PR China.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Cell Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity Related Publications

• A "moonlighting" dizinc aminopeptidase from Streptomyces griseus: mechanisms for peptide hydrolysis and the 4 x 10(10)-fold acceleration of the alternative phosphodiester hydrolysis.
• Catechol oxidase activity of di-Cu2+-substituted aminopeptidase from Streptomyces griseus.
• Compound salvia droplet pill, a traditional Chinese medicine, for the treatment of unstable angina pectoris: A systematic review.
• Construction of a sequence-tagged high-density genetic map of papaya for comparative structural and evolutionary genomics in brassicales.
• Crucial effects of coupling coefficients on quasi-phase-matched harmonic generation in an optical superlattice.
• Crucial effects of coupling coefficients on quasi-phase-matched harmonic generation in an optical superlattice: errata.
• Effect of interleukin-1beta on I(A) and I(K) currents in cultured murine trigeminal ganglion neurons.
• Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety.
• Ginkgolides protect PC12 cells against hypoxia-induced injury by p42/p44 MAPK pathway-dependent upregulation of HIF-1alpha expression and HIF-1DNA-binding activity.
• Investment in body image among patients diagnosed with or at risk for malignant melanoma.
• Low X/Y divergence in four pairs of papaya sex-linked genes.
• Methodology and reporting quality of systematic review/meta-analysis of traditional Chinese medicine.
• New Hepatoprotective Triterpenes form Canarium album.
• New method for high-performance liquid chromatographic determination of amantadine and its analogues in rat plasma.
• P47.09: Late abortion for fetal anomalies: ten case experiences in one tertiary center in Taiwan and report of a novel method (fetal cardiac tamponade).
• Second-harmonic generation in quasi-periodically domain-inverted Sr(0.6) Ba(0.4) Nb(2)O(6) optical superlattices.
• TGIF, a gene associated with human brain defects, regulates neuronal development.
• The Influence of Dynamic Trans-tibial Prosthetic Alignment on Standing Plantar Foot Pressure.
• Third-harmonic generation in a general two-component quasi-periodic optical superlattice.
• Tissue differential expression of lycopene beta-cyclase gene in papaya.
• [Alteration in serum cytokines of patients with multiple organ dysfunction syndrome after liver transplantation]
• [Assessment and nursing care of patients in acute confusion in intensive care units.]
• [Management of nutritional support and stress hyperglycemia after orthotopic liver transplantation]
• [Research on the progress of neuroprosthesis for the limb motor system]
• [SPG3A-hereditary spastin paraplegia with genetic anticipation and incomplete penetrance]
• [Study on spectrophotometric determination of trace nitrite with brilliant cresol blue]
• [Study on the hepatoxicity mechanisms of huangyaozi (Rhizoma dioscoreae bulbiferae) on mouse liver by cDNA microarray]
• [Trachoma in Singapore]
• [Treatment of complex acetabular fractures by a modified extended iliofemoral approach]
• [Treatment of mandibular retrusion patients with Forsus appliance following growth spurts]