Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence.

Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Research Abstract Details 

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Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Abstract Text:

Bin Ye,Margarita Aponte,Yan Dai,Lily Li,Ming-Chih D Ho,Allison Vitonis,Dale Edwards,Tai-Nang Huang,Daniel W Cramer,

There is considerable interest in herbal therapies for cancer prevention but often with little scientific evidence to support their use. In this study, we examined epidemiological data regarding effects of commonly used herbal supplements on risk for ovarian cancer and sought supporting biological evidence. 4.2% of 721 controls compared to 1.6% of 668 cases regularly used Ginkgo biloba for an estimated relative risk (and 95% confidence interval) of 0.41 (0.20,0.84) (p=0.01); and the effect was most apparent in women with non-mucinous types of ovarian cancer, RR=0.33 (0.15,0.74) (p=0.007). In vitro experiments with normal and ovarian cancer cells showed that Ginkgo extract and its components, quercetin and ginkgolide A and B, have significant anti-proliferative effects ( approximately 40%) in serous ovarian cancer cells, but little effect in mucinous (RMUG-L) cells. For the ginkgolides, the inhibitory effect appeared to be cell cycle blockage at G0/G1 to S phase. This combined epidemiological and biological data provide supportive evidence for further studies of the chemopreventive or therapeutic effects of Ginkgo and ginkgolides on ovarian cancer.

Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Publishing Authors By Initials

B Ye,M Aponte,Y Dai,L Li,MC Ho,A Vitonis,D Edwards,TN Huang,DW Cramer,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: chromones: flavonoids: flavonols: quercetin research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: chromones: flavonoids: flavonols: quercetin research

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Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cancer letters

VOLUME: 251

Page Numbers: 43-52

Journal Abbreviation:

ISSN: 0304-3835

DAY: 27

MONTH: 12

YEAR: 2006

Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600053

Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Keywords Mesh Terms:

KEYWORDS: Quercetin

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Information

Substance Name: ginkgolide B

Registry Number: 99796-69-7

Grant and Affiliation Information for Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence.

AFFILIATION: Laboratory of Gynecologic Oncology and Epidemiology, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Dana-Farber Cancer Center, USA. bye@partners.org

Country: Ireland

AGENCY: United States NCI

GRANT: R21 CA111949-01

ACRONYM: CA

MEDLINETA: Cancer Lett

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