Ghrelin promotes thymopoiesis during aging.

Ghrelin promotes thymopoiesis during aging. Research Abstract Details 

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Ghrelin promotes thymopoiesis during aging. Abstract Text:

Vishwa Deep Dixit,Hyunwon Yang,Yuxiang Sun,Ashani T Weeraratna,Yun-Hee Youm,Roy G Smith,Dennis D Taub,

The decline in adaptive immunity, T lymphocyte output, and the contraction of the TCR repertoire with age is largely attributable to thymic involution. The loss of thymic function with age may be due to diminished numbers of progenitors and the loss of critical cytokines and hormones from the thymic microenvironment. We have previously demonstrated that the orexigenic hormone ghrelin is expressed by immune cells and regulates T cell activation and inflammation. Here we report that ghrelin and ghrelin receptor expression within the thymus diminished with progressive aging. Infusion of ghrelin into 14-month-old mice significantly improved the age-associated changes in thymic architecture and thymocyte numbers, increasing recent thymic emigrants and improving TCR diversity of peripheral T cell subsets. Ghrelin-induced thymopoiesis during aging was associated with enhanced early thymocyte progenitors and bone marrow-derived Lin(-)Sca1(+)cKit(+) cells, while ghrelin- and growth hormone secretagogue receptor-deficient (GHS-R-deficient) mice displayed enhanced age-associated thymic involution. Leptin also enhanced thymopoiesis in aged but not young mice. Our findings demonstrate what we believe to be a novel role for ghrelin and its receptor in thymic biology and suggest a possible therapeutic benefit of harnessing this pathway in the reconstitution of thymic function in immunocompromised subjects.

Ghrelin promotes thymopoiesis during aging. Publishing Authors By Initials

VD Dixit,H Yang,Y Sun,AT Weeraratna,YH Youm,RG Smith,DD Taub,

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Ghrelin promotes thymopoiesis during aging. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: The Journal of clinical investigation

VOLUME: 117

Page Numbers: 2778-90

Journal Abbreviation: J. Clin. Invest.

ISSN: 0021-9738

DAY: 27

MONTH: Oct

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 7802877

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AFFILIATION: Clinical Immunology Section, Laboratory of Immunology, Intramural Research Program, National Institute on Aging, NIH, Baltimore, Maryland, USA. vishwa.dixit@pbrc.edu

Country: United States

AGENCY: United States NIA

GRANT: R01 AG19230-01

ACRONYM: AG

MEDLINETA: J Clin Invest

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