Ghrelin inhibits sympathetic nervous activity in sepsis.

Ghrelin inhibits sympathetic nervous activity in sepsis. Research Abstract Details 

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Ghrelin inhibits sympathetic nervous activity in sepsis. Abstract Text:

Rongqian Wu,Mian Zhou,Padmalaya Das,Weifeng Dong,Youxin Ji,Derek Yang,Michael Miksa,Fangming Zhang,Thanjavur S Ravikumar,Ping Wang,Rongqian Wu,Mian Zhou,Padmalaya Das,Weifeng Dong,Youxin Ji,Derek Yang,Michael Miksa,Fangming Zhang,Thanjavur S Ravikumar,Ping Wang,

Our previous studies have shown that norepinephrine (NE) upregulates proinflammatory cytokines by activating alpha(2)-adrenoceptor. Therefore, modulation of the sympathetic nervous system represents a novel treatment for sepsis. We have also shown that a novel stomach-derived peptide, ghrelin, is downregulated in sepsis and that its intravenous administration decreases proinflammatory cytokines and mitigates organ injury. However, it remains unknown whether ghrelin inhibits sympathetic activity through central ghrelin receptors [i.e., growth hormone secretagogue receptor 1a (GHSR-la)] in sepsis. To study this, sepsis was induced in male rats by cecal ligation and puncture (CLP). Ghrelin was administered through intravenous or intracerebroventricular injection 30 min before CLP. Our results showed that intravenous administration of ghrelin significantly reduced the elevated NE and TNF-alpha levels at 2 h after CLP. NE administration partially blocked the inhibitory effect of ghrelin on TNF-alpha in sepsis. GHSR-la inhibition by the administration of a GHSR-la antagonist, [d-Arg(1),d-Phe(5), d-Trp(7,9),Leu(11)]substance P, significantly increased both NE and TNF-alpha levels even in normal animals. Markedly elevated circulating levels of NE 2 h after CLP were also significantly decreased by intracerebroventricular administration of ghrelin. Ghrelin's inhibitory effect on NE release was completely blocked by intracerebroventricular injection of the GHSR-1a antagonist or a neuropeptide Y (NPY)/Y(1) receptor antagonist. However, ghrelin's downregulatory effect on TNF-alpha release was only partially diminished by these agents. Thus ghrelin has sympathoinhibitory properties that are mediated by central ghrelin receptors involving a NPY/Y1 receptor-dependent pathway. Ghrelin's inhibitory effect on TNF-alpha production in sepsis is partially because of its modulation of the overstimulated sympathetic nerve activation.

Ghrelin inhibits sympathetic nervous activity in sepsis. Publishing Authors By Initials

R Wu,M Zhou,P Das,W Dong,Y Ji,D Yang,M Miksa,F Zhang,TS Ravikumar,P Wang,R Wu,M Zhou,P Das,W Dong,Y Ji,D Yang,M Miksa,F Zhang,TS Ravikumar,P Wang,

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Ghrelin inhibits sympathetic nervous activity in sepsis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of physiology. Endocrinology and

VOLUME: 293

Page Numbers: E1697-702

Journal Abbreviation: Am. J. Physiol. Endocrinol. Me

ISSN: 0193-1849

DAY: 2

MONTH: 10

YEAR: 2007

Ghrelin inhibits sympathetic nervous activity in sepsis. Information

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LANGUAGE: eng

NlmUniqueID: 100901226

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AFFILIATION: The Feinstein Institute for Medical Research, 350 Community Dr., Manhasset, NY 11030. pwang@nshs.edu).

Country: United States

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MEDLINETA: Am J Physiol Endocrinol Metab

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