Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice.

Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Research Abstract Details 

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Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Abstract Text:

Amanda M Shaw,Boman G Irani,Marcus C Moore,Carrie Haskell-Luevano,William J Millard,

Ghrelin stimulates food intake in part by activating hypothalamic neuropeptide Y (NPY) neurons/agouti related peptide (AGRP) neurons. We investigated the role of AGRP/melanocortin signaling in ghrelin-induced food intake by studying melanocortin 3 and 4 receptor knockout (MC3R KO and MC4R KO) mice. We also determined whether reduced ghrelin levels and/or an altered sensitivity to the GH-stimulating effects of ghrelin accompany the obesity syndromes of MC3R KO and MC4R KO mice. Compared to wild-type (WT) mice, the effects of ghrelin on food intake were reduced in MC3R KO and MC4R KO mice and circulating ghrelin levels were reduced in female MC4R KO mice. Female MC3R KO and MC4R KO mice exhibited a diminished responsiveness to the GH-releasing effects of ghrelin. Thus, deletion of the MC3R or MC4R results in a decreased sensitivity to ghrelin and verifies the involvement in the melanocortin system in ghrelin-induced food intake.

Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Publishing Authors By Initials

AM Shaw,BG Irani,MC Moore,C Haskell-Luevano,WJ Millard,

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Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Peptides

VOLUME: 26

Page Numbers: 1720-7

Journal Abbreviation: Peptides

ISSN: 0196-9781

DAY: 5

MONTH: Oct

YEAR: 2005

Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008690

Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Keywords Mesh Terms:

KEYWORDS: Receptor, Melanocortin, Type 4

MESH TERMS: genetics

Chemical & Substance for Abstract: Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Ghrelin-induced food intake and growth hormone secretion are altered in melanocortin 3 and 4 receptor knockout mice.

AFFILIATION: Department of Pharmacodynamics, University of Florida, 1600 SW Archer Rd., JHMHC, Box 100487, Gainesville, FL 32610, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK-57080

ACRONYM: DK

MEDLINETA: Peptides

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