Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep.

Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep. Research Abstract Details 

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Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep. Abstract Text:

Hideyuki Takahashi,Yohei Kurose,Muneyuki Sakaida,Yoshihiro Suzuki,Shigeki Kobayashi,Toshihisa Sugino,Masayasu Kojima,Kenji Kangawa,Yoshihisa Hasegawa,Yoshiaki Terashima,

The present study was conducted to investigate roles of ghrelin in glucose-induced insulin secretion in fasting- and meal-fed state in sheep. Castrated Suffolk rams were fed a maintenance diet of alfalfa hay cubes once a day. Hyperglycemic clamp (HGC) was carried out to examine glucose-induced insulin response from 48 to 53 h (fasting state) and from 3 to 8 h (meal-fed state) after feeding in Experiment 1 and 2 respectively. Total dose of 70 nmol/kg body weight of D-Lys3-GHRP6, a GH secretagogue receptor 1a (GHS-R1a) antagonist, was intravenously administered at 0, 60, and 120 min after the commencement of HGC. In the fasting state, the ghrelin antagonist significantly (P < 0.01) enhanced glucose-induced insulin secretion. In the meal-fed state, i.v. administration of synthetic ovine ghrelin (0.04 microg/kg body weight per min during HGC) significantly (P < 0.05) enhanced glucose-induced insulin secretion. d-Lys3-GHRP6 treatment suppressed ghrelin-induced enhancement of the insulin secretion. In conclusion, ghrelin has an inhibitory and stimulatory role in glucose-induced insulin secretion via GHS-R1a in fasting- and meal-fed state respectively.

Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep. Publishing Authors By Initials

H Takahashi,Y Kurose,M Sakaida,Y Suzuki,S Kobayashi,T Sugino,M Kojima,K Kangawa,Y Hasegawa,Y Terashima,

For similar animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep research

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Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of endocrinology

VOLUME: 194

Page Numbers: 621-5

Journal Abbreviation: J. Endocrinol.

ISSN: 0022-0795

DAY: 20

MONTH: Sep

YEAR: 2007

Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep. Information

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LANGUAGE: eng

NlmUniqueID: 375363

Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep. Keywords Mesh Terms:

KEYWORDS: Sheep

MESH TERMS: drug effects

Chemical & Substance for Abstract: Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Ghrelin differentially modulates glucose-induced insulin secretion according to feeding status in sheep.

AFFILIATION: School of Veterinary Medicine and Animal Science, Kitasato University, Towada-shi, Aomori 034-8628, Japan.

Country: England

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MEDLINETA: J Endocrinol

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