Ghrelin and the enteroinsular axis in healthy men.

Ghrelin and the enteroinsular axis in healthy men. Research Abstract Details 

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Ghrelin and the enteroinsular axis in healthy men. Abstract Text:

Dragan Micic,Leonidas Duntas,Goran Cvijovic,Aleksandra Kendereski,Mirjana Sumarac-Dumanovic,Peter Jehle,Svetlana Zoric,Danica Pejkovic,Mary Lague,Carlos Dieguez,Felipe Casanueva,Dragan Micic,Leonidas Duntas,Goran Cvijovic,Aleksandra Kendereski,Mirjana Sumarac-Dumanovic,Peter Jehle,Svetlana Zoric,Danica Pejkovic,Mary Lague,Carlos Dieguez,Felipe Casanueva,Dragan Micic,Leonidas Duntas,Goran Cvijovic,Aleksandra Kendereski,Mirjana Sumarac-Dumanovic,Peter Jehle,Svetlana Zoric,Danica Pejkovic,Mary Lague,Carlos Dieguez,Felipe Casanueva,

OBJECTIVE: Ghrelin, a potent stimulator of GH secretion, also acts as an orexigenic hormone. Plasma ghrelin levels rise before meals with postprandial reduction, suggesting that circulating levels of enteroinsular hormones might influence ghrelin secretion. AIM: The aim of this study was to evaluate the effects of ghrelin on enteroinsular hormones in healthy men. DESIGN: Three tests were performed on 3 different days in 6 healthy men: On the first day, saline was infused from 0-120 minutes followed by a ghrelin bolus (1 microg/kg) administration (Test 1); on the second experimental day, GHRH was administered at 0 min, and a ghrelin bolus was given at 120 min (Test 2); on the third experimental day, GHRP-6 was administered at 0 min, followed by a ghrelin bolus at 120 min (Test 3). Plasma glucose, insulin, proinsulin, C-Peptide Glucagone Like Peptide one (GLP-1) determined at 0, 15, 30, 60, 90, and 120 min of the test period. RESULTS: There was a significant increase in AUC glucose (526.41+/-22.91 mmol . ml(-1) . min vs. 566.37+/-15.64 mmol . ml(-1) . min; p<0.05) and AUC insulin (756.25+/-107.56 mU . ml(-1) . min vs. 981.62+/-180.32 mU . ml(-1) . min; p<0.05) and a significant decrease in AUC GLP-1 (2346.87+/-874.28 pmol . ml(-1) . min vs. 1769.5+/-784 pmol . ml(-1) . min; p<0.05) after ghrelin administration in Test 1 compared to Test 3. There was a mild but non-significant increase in AUC for insulin, proinsulin, and C-Peptide and a mild reduction in AUC GLP-1 after every ghrelin administration. CONCLUSION: There was no evidence of a direct effect of ghrelin administration on enteroinsular hormone levels in this study. However, ghrelin may potentiate the glucose-insulin stimulatory effects of GHRP-6. More studies should be carried out for further evaluation of ghrelin-enteroinsular hormones interplay.

Ghrelin and the enteroinsular axis in healthy men. Publishing Authors By Initials

D Micic,L Duntas,G Cvijovic,A Kendereski,M Sumarac-Dumanovic,P Jehle,S Zoric,D Pejkovic,M Lague,C Dieguez,F Casanueva,D Micic,L Duntas,G Cvijovic,A Kendereski,M Sumarac-Dumanovic,P Jehle,S Zoric,D Pejkovic,M Lague,C Dieguez,F Casanueva,D Micic,L Duntas,G Cvijovic,A Kendereski,M Sumarac-Dumanovic,P Jehle,S Zoric,D Pejkovic,M Lague,C Dieguez,F Casanueva,

For similar hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: pancreatic hormones: proinsulin research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: pancreatic hormones: proinsulin research

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Ghrelin and the enteroinsular axis in healthy men. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hormones (Athens, Greece)

VOLUME: 6

Page Numbers: 321-6

Journal Abbreviation:

ISSN: 1109-3099

DAY: 6

MONTH: 02

YEAR: 2008

Ghrelin and the enteroinsular axis in healthy men. Information

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LANGUAGE: eng

NlmUniqueID: 101142469

Ghrelin and the enteroinsular axis in healthy men. Keywords Mesh Terms:

KEYWORDS: Proinsulin

MESH TERMS: blood

Chemical & Substance for Abstract: Ghrelin and the enteroinsular axis in healthy men. Information

Substance Name: Proinsulin

Registry Number: 9035-68-1

Grant and Affiliation Information for Ghrelin and the enteroinsular axis in healthy men.

AFFILIATION: Institute of Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Belgrade, Serbia. micicd@eunet.yu

Country: Greece

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MEDLINETA: Hormones (Athens)

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