Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring.

Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Research Abstract Details 

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Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Abstract Text:

Sally S White,Antonia M Calafat,Zsuzsanna Kuklenyik,LaTonya Villanueva,Robert D Zehr,Laurence Helfant,Mark J Strynar,Andrew B Lindstrom,Julie R Thibodeaux,Carmen Wood,Suzanne E Fenton,

Perfluorooctanoic acid (PFOA), with diverse and widespread commercial and industrial applications, has been detected in human and wildlife sera. Previous mouse studies linked prenatal PFOA exposure to decreased neonatal body weights (BWs) and survival in a dose-dependent manner. To determine whether effects were linked to gestational time of exposure or to subsequent lactational changes, timed-pregnant CD-1 mice were orally dosed with 5 mg PFOA/kg on gestation days (GD) 1-17, 8-17, 12-17, or vehicle on GD 1-17. PFOA exposure had no effect on maternal weight gain or number of live pups born. Mean pup BWs on postnatal day (PND) 1 in all PFOA-exposed groups were significantly reduced and decrements persisted until weaning. Mammary glands from lactating dams and female pups on PND 10 and 20 were scored based on differentiation or developmental stages. A significant reduction in mammary differentiation among dams exposed GD 1-17 or 8-17 was evident on PND 10. On PND 20, delays in normal epithelial involution and alterations in milk protein gene expression were observed. All exposed female pups displayed stunted mammary epithelial branching and growth at PND 10 and 20. While control litters at PND 10 and 20 had average scores of 3.1 and 3.3, respectively, all treated litters had scores of 1.7 or less, with no progression of duct epithelial growth evident over time. BW was an insignificant covariate for these effects. These findings suggest that in addition to gestational exposure, abnormal lactational development of dams may play a role in early growth retardation of developmentally exposed offspring.

Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Publishing Authors By Initials

SS White,AM Calafat,Z Kuklenyik,L Villanueva,RD Zehr,L Helfant,MJ Strynar,AB Lindstrom,JR Thibodeaux,C Wood,SE Fenton,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Toxicological sciences : an official journal of th

VOLUME: 96

Page Numbers: 133-44

Journal Abbreviation: Toxicol. Sci.

ISSN: 1096-6080

DAY: 28

MONTH: 11

YEAR: 2006

Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9805461

Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: toxicity

Chemical & Substance for Abstract: Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring. Information

Substance Name: perfluorooctanoic acid

Registry Number: 335-67-1

Grant and Affiliation Information for Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring.

AFFILIATION: Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: 5-T32ES001726-22

ACRONYM: ES

MEDLINETA: Toxicol Sci

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