Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes.

Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Research Abstract Details 

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Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Abstract Text:

Darcy B Carr,Kristina M Utzschneider,Rebecca L Hull,Jenny Tong,Tara M Wallace,Keiichi Kodama,Jane B Shofer,Susan R Heckbert,Edward J Boyko,Wilfred Y Fujimoto,Steven E Kahn,

OBJECTIVE: We sought to determine whether a history of gestational diabetes mellitus (GDM) further increases the risk of cardiovascular disease (CVD) in parous women with first-degree relatives with type 2 diabetes. RESEARCH DESIGN AND METHODS: Women with (n = 332) and without (n = 663) a history of GDM were compared regarding 1) the revised National Cholesterol Education Program Adult Treatment Panel III metabolic syndrome criteria, 2) the prevalence of type 2 diabetes, and 3) self-reported CVD. RESULTS: Women with prior GDM were younger (48.6 +/- 0.7 vs. 52.4 +/- 0.6 years [means +/- SE];P < 0.001) and less likely to be postmenopausal (48.3 vs. 57.9%; P < 0.005). Although both groups were obese (BMI 34.4 +/- 1.2 vs. 33.7 +/- 0.6 kg/m(2)), women with prior GDM were more likely to have metabolic syndrome (86.6 vs. 73.5%; P < 0.001) and type 2 diabetes (93.4 vs. 63.3%; P < 0.001). Moreover, they had a higher prevalence of CVD (15.5 vs. 12.4%; adjusted odds ratio 1.85 [95% CI 1.21-2.82];P = 0.005) that occurred at a younger age (45.5 +/- 2.2 vs. 52.5 +/- 1.9 years;P = 0.02) and was independent of metabolic syndrome (1.74 [1.10-2.76]; P = 0.02) and type 2 diabetes (1.56 [1.002-2.43];P < 0.05). CONCLUSIONS: Among women with a family history of type 2 diabetes, those with prior GDM were even more likely to not only have CVD risk factors, including metabolic syndrome and type 2 diabetes, but also to have experienced CVD events, which occurred at a younger age. Thus, women with both a family history of type 2 diabetes and personal history of GDM may be especially suitable for early interventions aimed at preventing or reducing their risk of CVD and diabetes.

Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Publishing Authors By Initials

DB Carr,KM Utzschneider,RL Hull,J Tong,TM Wallace,K Kodama,JB Shofer,SR Heckbert,EJ Boyko,WY Fujimoto,SE Kahn,

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Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Diabetes care

VOLUME: 29

Page Numbers: 2078-83

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ISSN: 0149-5992

DAY: 3

MONTH: Sep

YEAR: 2006

Gestational diabetes mellitus increases the risk of cardiovascular disease in women with a family history of type 2 diabetes. Information

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LANGUAGE: eng

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AFFILIATION: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA 98195-6460, USA. darcarr@u.washington.edu

Country: United States

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MEDLINETA: Diabetes Care

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