Germ-line DNA copy number variation frequencies in a large North American population.

Germ-line DNA copy number variation frequencies in a large North American population. Research Abstract Details 

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Germ-line DNA copy number variation frequencies in a large North American population. Abstract Text:

George Zogopoulos,Kevin C H Ha,Faisal Naqib,Sara Moore,Hyeja Kim,Alexandre Montpetit,Frederick Robidoux,Philippe Laflamme,Michelle Cotterchio,Celia Greenwood,Stephen W Scherer,Brent Zanke,Thomas J Hudson,Gary D Bader,Steven Gallinger,George Zogopoulos,Kevin C H Ha,Faisal Naqib,Sara Moore,Hyeja Kim,Alexandre Montpetit,Frederick Robidoux,Philippe Laflamme,Michelle Cotterchio,Celia Greenwood,Stephen W Scherer,Brent Zanke,Thomas J Hudson,Gary D Bader,Steven Gallinger,

Genomic copy number variation (CNV) is a recently identified form of global genetic variation in the human genome. The Affymetrix GeneChip 100 and 500 K SNP genotyping platforms were used to perform a large-scale population-based study of CNV frequency. We constructed a genomic map of 578 CNV regions, covering approximately 220 Mb (7.3%) of the human genome, identifying 183 previously unknown intervals. Copy number changes were observed to occur infrequently (<1%) in the majority (>93%) of these genomic regions, but encompass hundreds of genes and disease loci. This North American population-based map will be a useful resource for future genetic studies.

Germ-line DNA copy number variation frequencies in a large North American population. Publishing Authors By Initials

G Zogopoulos,KC Ha,F Naqib,S Moore,H Kim,A Montpetit,F Robidoux,P Laflamme,M Cotterchio,C Greenwood,SW Scherer,B Zanke,TJ Hudson,GD Bader,S Gallinger,G Zogopoulos,KC Ha,F Naqib,S Moore,H Kim,A Montpetit,F Robidoux,P Laflamme,M Cotterchio,C Greenwood,SW Scherer,B Zanke,TJ Hudson,GD Bader,S Gallinger,

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Germ-line DNA copy number variation frequencies in a large North American population. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Human genetics

VOLUME: 122

Page Numbers: 345-53

Journal Abbreviation: Hum. Genet.

ISSN: 0340-6717

DAY: 19

MONTH: 07

YEAR: 2007

Germ-line DNA copy number variation frequencies in a large North American population. Information

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LANGUAGE: eng

NlmUniqueID: 7613873

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Grant and Affiliation Information for Germ-line DNA copy number variation frequencies in a large North American population.

AFFILIATION: Sam Minuk Cancer Genetics and Biomarker Laboratories, Fred Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute, Toronto, Canada.

Country: Germany

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MEDLINETA: Hum Genet

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