Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease.

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease. Abstract Text:

Laurence Barrier,Sabrina Ingrand,Milena Damjanac, Bilan,Jacques Hugon, Page,Laurence Barrier,Sabrina Ingrand,Milena Damjanac, Rioux Bilan,Jacques Hugon, Page,

In this study, brain gangliosides of different transgenic mouse models of Alzheimer's disease (AD) were analyzed and compared with age-matched wild-type mice. Gangliosides were analyzed in cerebral cortex, a region with extensive A beta plaques, and cerebellum, a non-vulnerable region with no A beta containing plaques. There was a marked increase in simple gangliosides GM2 and GM3 only within the cortex of all mice expressing APP(SL). Additionally, loss of complex "a" gangliosides (GT1a, GD1a and GM1) was recorded in APP/PS1Ki model, whereas in APP(SL) and APP/PS1 mice, the complex "b" gangliosides (GQ1b, GT1b and GD1b) moderately decreased. Surprisingly, expression of either mutant PS1(M146L) or PS1 mutant FAD (Ki model) alone tended to lower the levels of both GM2 and GM3 within the cortex. Conversely, only slight changes of the ganglioside pattern were found in the cerebellum. Because ganglioside alterations occurring in APP transgenic mice were similar to those observed in human AD brain, these transgenic models would represent valuable tools to further investigate the role of altered ganglioside metabolism in the pathogenesis of AD.

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease. Publishing Authors By Initials

L Barrier,S Ingrand,M Damjanac,AR Bilan,J Hugon,G Page,L Barrier,S Ingrand,M Damjanac,A Rioux Bilan,J Hugon,G Page,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

PUBMED ID PMID:

MEDLINE DATE:

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 1863-72

Journal Abbreviation: Neurobiol. Aging

ISSN: 1558-1497

DAY: 27

MONTH: 09

YEAR: 2006

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8100437

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: metabolism

Chemical & Substance for Abstract: Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease. Information

Substance Name: Gangliosides

Registry Number: 0

Grant and Affiliation Information for Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease.

AFFILIATION: Groupe de Recherche sur le Vieillissement Cérébral, GReViC EA 3808, Faculté de Médecine et de Pharmacie, 34, rue du Jardin des Plantes, BP 199, 86005 Poitiers Cedex, France. lbarrier@univ-poitiers.fr

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Neurobiol Aging

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Genotype-related changes of ganglioside composition in brain regions of transgenic mouse models of Alzheimer's disease Related Publications

• 142.
• A comparison of transcriptomic and metabonomic technologies for identifying biomarkers predictive of two-year rodent cancer bioassays.
• An audit of health products and services marketed on chiropractic websites in Alberta and consideration of these practices in the context of chiropractic codes of conduct and ethics.
• Are there long-term consequences of pain in newborn or very young infants?
• Assessment of polycyclic aromatic hydrocarbon exposure in the waters of Prince William Sound after the Exxon Valdez oil spill: 1989-2005.
• Behavioral genomics of honeybee foraging and nest defense.
• Circadian regulation of insect olfactory learning.
• CpG DNA modulates interleukin 1beta-induced interleukin-8 expression in human bronchial epithelial (16HBE14o-) cells.
• Current Concepts in Menthol-based Topical Analgesics for Pain Relief: 2087: Board #157 May 31 2:00 PM - 3:30 PM.
• Effects of experimental endogenous hyperlipemia on circulating leukocytes and erythrocytes.
• Expert commentary.
• Freezing bovine embryos with a portable liquid nitrogen freezer requiring no external seeding.
• German cockroach frass proteases cleave pro-matrix metalloproteinase-9.
• Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?
• Hs04 the use of a visual hand chart to aid in communication of hand injuries.
• Hsp72 induces inflammation and regulates cytokine production in airway epithelium through a TLR4- and NF-kappaB-dependent mechanism.
• Late presentation of congenital bochdalek hernia: a case report.
• Patient response in a screened population for interstitial cystitis.
• Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporin A in tumor-bearing cats.
• Psychotherapies for hypochondriasis.
• Reduced dosage of pos-1 suppresses Mex mutants and reveals complex interactions among CCCH zinc-finger proteins during Caenorhabditis elegans embryogenesis.
• Regulation of life history determines lifespan of worker honey bees (Apis mellifera L.).
• SIR 2006 annual meeting film panel case: polyarteritis nodosa in upper extremity arteries.
• Shrinking to fit: fluid jettison from a haemocoelic hydrostatic skeleton during defensive withdrawals of a gastropod larva.
• Strategies to maximize heterologous protein expression in Escherichia coli with minimal cost.
• Stroke in former prisoners of war.
• The effect of freezer type, cryoprotectant, and processing methods on viability of frozen embryos.
• The quantitation of bovine embryo viability using a bioluminescent assay for lactate dehydrogenase.
• The relationship of parental overprotection, perceived child vulnerability, and parenting stress to uncertainty in youth with chronic illness.
• Treating systemic effects of COPD.