Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene.

Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene. Abstract Text:

I Kato,J Eastham,B Li,M Smith,H Yu,

Polymorphic microsatellite dinucleotide (cytosine-adenine, CA) repeats of the insulin-like growth factor-I (IGF-I) gene may have implications in the development of certain types of cancer and osteoporosis. We studied correlations between IGF-I genotypes determined by direct sequencing and plasma IGF-I levels among 113 healthy individuals (60 men and 53 women), who were originally enrolled as controls for hospital-based case-control studies of breast and prostate cancer. On the contrary to an earlier observation, there were no differences in plasma IGF-I levels between those with and without the allele of 19 repeats. With adjustment for other confounders, there were no trends in plasma IGF-I levels with increasing or decreasing the number of CA repeats among all study subjects combined, all Whites or all Blacks, suggesting no overall functional significance of this polymorphism. Opposite trends observed in gender and racial subgroups, i.e., an inverse association between plasma IGF-I levels and the CA repeat length in white women and a positive association in black men, are likely to be chance findings.

Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene. Publishing Authors By Initials

I Kato,J Eastham,B Li,M Smith,H Yu,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: European journal of epidemiology

VOLUME: 18

Page Numbers: 203-9

Journal Abbreviation: Eur. J. Epidemiol.

ISSN: 0393-2990

DAY: 12

MONTH: 06

YEAR: 2003

Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8508062

Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene.

AFFILIATION: Karmanos Cancer Institute/Department of Pathology Wayne State University, Detroit, Michigan 48201, USA. katoi@karmanos.org

Country: Netherlands

AGENCY: United States NCI

GRANT: CA 83050

ACRONYM: CA

MEDLINETA: Eur J Epidemiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I IGF-I gene Related Publications

• An overview of vagal airway receptors.
• Element mixing distribution and structure feature of fusion zone in laser welding between different alloys and pure titanium.
• Endothelial function and carotid artery wall thickening in patients with early essential hypertension.
• Genetic factors underlying prostate cancer.
• Genotype-phenotype analysis for the polymorphic CA repeat in the insulin-like growth factor-I (IGF-I) gene.
• Na(+)/K(+) -ATPase as a marker for detecting pulmonary sensory receptors.
• RRR-alpha-tocopheryl succinate inhibits human gastric cancer SGC-7901 cell growth by inducing apoptosis and DNA synthesis arrest.
• The effects of vitamin E succinate on the expression of c-jun gene and protein in human gastric cancer SGC-7901 cells.
• [A case of sepsis and multiple organ dysfunction syndrome complicated by Staphylococcus infection]
• [Anisodamine in prevention and treatment of sepsis of severely burned patients]
• [Association study on HLA-DP and -DQ allelic polymorphisms and nasopharyngeal carcinoma in the Han nationality in Hunan province]
• [Change of catecholamine in serum and hippocampus of rats after electromagnetic irradiation and the selection of protective site]
• [Changes of phosphorylation states of Cx43 protein in Chinese hamster lung cells induced by SiO2]
• [Double uterus and hydatidiform mole in the malformed uterus: report of one case]
• [Early diagnosis of pancreatic cancer is essential to improving the effect of treatment]
• [Effect of oxidated low-density lipoprotein on early apoptosis of vascular smooth muscle cell]
• [Extinguishment of harmful algae by organo-clay]
• [Humoral immune response in mice to hybrid nucleic acid vaccines containing Plasmodium falciparum merozoite surface protein 1 block 17-based gene]
• [PCR in detecting the correlation between infection of HBV and cholelithiasis]
• [Post-mastectomy radiotherapy with different fractionated dose schemes in early breast cancer]
• [Primary extranodal lymphomas: analyses of clinical characteristics and misdiagnoses of 139 cases]
• [Relationship between Helicobacter pylori infection and expression of c-myc, Bcl-2, and Bax protein in different gastric mucosa lesions]
• [Researches in forensic biomechanics]
• [Study on antitumor effect and mechanism of aloe polysaccharides]
• [Study on the genic polymorphism of HLA-DRB1 in a population in the north of China]
• [The effect of radix Pseudostellariae from 8 habitats on spleen-deficiency and immunologic function]
• [The expression and activity of caspase-8 in the process of vitamin E succinate-induced apoptosis in human gastric carcinoma SGC-7901 cells]
• [Treatment of burns combined injury]
• [Wavelet feature extraction and classification of Doppler ultrasound blood flow signals]
• [p15 gene expression in acute lymphoblastic leukemia cell line Molt4 induced by arsenic trioxide]