Genomic screen for substance dependence and body mass index in southwest California Indians.

Genomic screen for substance dependence and body mass index in southwest California Indians. Research Abstract Details 

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Genomic screen for substance dependence and body mass index in southwest California Indians. Abstract Text:

Cindy L Ehlers,Kirk C Wilhelmsen,

Substance abuse and obesity are health disparities that may afflict Native Americans more than some other ethnic groups. One theoretical assumption concerning Native people is that the long history of dependence on foraging and subsistence agriculture may have led to selective enrichment of traits that improve genetic fitness, so called 'thrifty' or 'fat sparing' genes. We have speculated that this same selective pressure may have enriched for genetic variants that increase the risk for consumption of alcohol and drugs of abuse. Here, we report the results of a genome scan that compared findings for two consumption phenotypes: 'any drug dependence and/or regular tobacco use' and body mass index (BMI) in southwest California (SWC) Indian families. Variance component analyses from SOLAR were used to generate log of the odds ratio (LOD) scores. Evidence for linkage was found on chromosome 6 for both the 'any drug' (LOD score = 3.3) and BMI (LOD score = 2.3) phenotypes. Bivariate analyses of the two phenotypes revealed a combined LOD score of 4.1 at that location. Additional loci on chromosomes 6, 15, 16 and 21 were found for the 'any drug' phenotype, and on chromosomes 8, 16 and 18 for BMI (LOD scores ranged between 1.2 and 2.3). These results provide suggestive evidence for linkage for substance abuse and BMI in this Mission Indian population and, furthermore, provide preliminary data suggesting that 'consumption phenotypes' may share some genetic determinants.

Genomic screen for substance dependence and body mass index in southwest California Indians. Publishing Authors By Initials

CL Ehlers,KC Wilhelmsen,

For similar disorders of environmental origin: substance-related disorders research abstracts see: disorders of environmental origin: substance-related disorders research

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Genomic screen for substance dependence and body mass index in southwest California Indians. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Genes, brain, and behavior

VOLUME: 6

Page Numbers: 184-91

Journal Abbreviation: Genes Brain Behav.

ISSN: 1601-1848

DAY: 3

MONTH: Mar

YEAR: 2007

Genomic screen for substance dependence and body mass index in southwest California Indians. Information

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LANGUAGE: eng

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Genomic screen for substance dependence and body mass index in southwest California Indians. Keywords Mesh Terms:

KEYWORDS: Substance-Related Disorders

MESH TERMS: genetics

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Grant and Affiliation Information for Genomic screen for substance dependence and body mass index in southwest California Indians.

AFFILIATION: Department of Molecular and Experimental Medicine, The Scripps Research Institute, USA. cindye@scripps.edu

Country: England

AGENCY: United States NCRR

GRANT: RR00833

ACRONYM: RR

MEDLINETA: Genes Brain Behav

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