Genomic screen for loci associated with alcohol dependence in Mission Indians.

Genomic screen for loci associated with alcohol dependence in Mission Indians. Research Abstract Details 

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Genomic screen for loci associated with alcohol dependence in Mission Indians. Abstract Text:

Alcohol dependence is a leading cause of morbidity and mortality in Native Americans, yet biological factors underlying the disorder in this ethnic group remain elusive. This study's aims were to map susceptibility loci for DSM-III-R alcohol dependence and two narrower alcohol-related phenotypes in Mission Indian families. Each participant gave a blood sample and completed an interview using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) that was used to make alcohol dependence diagnoses and the narrower phenotypes of withdrawal, and drinking severity. Genotypes were determined for a panel 791 microsatellite polymorphisms. Analyses of multipoint variance component LOD scores for the dichotomous DSM-III-R phenotype revealed no peak LOD scores that exceeded 2.0 at any chromosome location. Two chromosomes, 4 and 12, had peak LOD scores that exceeded 2 for the alcohol use severity phenotype and three chromosomes 6, 15, 16 were found to have peaks with LOD scores that exceeded 2 for the withdrawal phenotype. Evidence for linkage to chromosomes 4 and 15, and 16 have been reported previously for alcohol related phenotypes whereas no evidence has as yet been reported for chromosomes 6 and 12. Combined linkage and association analysis suggest that alcohol dehydrogenase 1B gene polymorphisms are partially responsible for the linkage result on chromosome 4 in this population. These results corroborate the importance of several chromosomal regions highlighted in prior segregation studies in alcoholism and further identify new regions of the genome that may be unique to either the restricted phenotypes evaluated or this population of Mission Indians.

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Genomic screen for loci associated with alcohol dependence in Mission Indians. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of medical genetics. Part B, Neur

VOLUME: 129B

Page Numbers: 110-5

Journal Abbreviation: Am. J. Med. Genet. B Neuropsyc

ISSN: 1552-4841

DAY: 15

MONTH: Aug

YEAR: 2004

Genomic screen for loci associated with alcohol dependence in Mission Indians. Information

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LANGUAGE: eng

NlmUniqueID: 101235742

Genomic screen for loci associated with alcohol dependence in Mission Indians. Keywords Mesh Terms:

KEYWORDS: Middle Aged

MESH TERMS: genetics

Chemical & Substance for Abstract: Genomic screen for loci associated with alcohol dependence in Mission Indians. Information

Substance Name: Alcohol Dehydrogenase

Registry Number: EC 1.1.1.1

Grant and Affiliation Information for Genomic screen for loci associated with alcohol dependence in Mission Indians.

AFFILIATION: Department of Neuropharmacology, The Scripps Research Institute, University of California, San Diego, California 92037, USA. cindye@scripps.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR00833

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MEDLINETA: Am J Med Genet B Neuropsychiat

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