Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer.

Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Research Abstract Details 

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Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Abstract Text:

Pamela L Paris,Matthias D Hofer,Giancarlo Albo,Rainer Kuefer,Juergen E Gschwend,Richard E Hautmann,Jane Fridyland,Jeffrey Simko,Peter R Carroll,Mark A Rubin,Colin Collins,

The progression of organ-confined prostate cancer to metastatic cancer is inevitably fatal. Consequently, identification of structural changes in the genome and associated transcriptional responses that drive this progression is critical to understanding the disease process and the development of biomarkers and therapeutic targets. In this study, whole genome copy number changes in genomes of hormone-naïve lymph node metastases were profiled using array comparative genomic hybridization, and matched primaries were included for a subset. Matched primaries and lymph node metastases showed very similar copy number profiles that are distinct from primary tumors that fail to metastasize.

Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Publishing Authors By Initials

PL Paris,MD Hofer,G Albo,R Kuefer,JE Gschwend,RE Hautmann,J Fridyland,J Simko,PR Carroll,MA Rubin,C Collins,

For similar biological factors: biological markers: tumor markers, biological research abstracts see: biological factors: biological markers: tumor markers, biological research

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Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neoplasia (New York, N.Y.)

VOLUME: 8

Page Numbers: 1083-9

Journal Abbreviation: Neoplasia

ISSN: 1476-5586

DAY: 3

MONTH: Dec

YEAR: 2006

Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Information

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LANGUAGE: eng

NlmUniqueID: 100886622

Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Keywords Mesh Terms:

KEYWORDS: Tumor Markers, Biological

MESH TERMS: genetics

Chemical & Substance for Abstract: Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Information

Substance Name: Tumor Markers, Biological

Registry Number: 0

Grant and Affiliation Information for Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer.

AFFILIATION: Department of Urology, University of California at San Francisco Comprehensive Cancer Center, San Francisco, CA 94115, USA.

Country: Canada

AGENCY: United States NCI

GRANT: P50CA89520

ACRONYM: CA

MEDLINETA: Neoplasia

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