Genomic instability in invasive breast carcinoma measured by inter-Simple Sequence Repeat PCR.

Genomic instability in invasive breast carcinoma measured by inter-Simple Sequence Repeat PCR. Research Abstract Details 

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Genomic instability in invasive breast carcinoma measured by inter-Simple Sequence Repeat PCR. Abstract Text:

Daniel L Stoler,Jeremy D Bartos,Helen Swede,Stephen B Edge,Janet S Winston,Sam M Wiseman,Garth R Anderson,

We have measured genomic instability in invasive breast carcinomas and assessed the relationship of genomic instability to known tumor prognostic factors. DNAs from tumors and adjacent normal tissue of 18 breast cancer patients were subjected to inter-Simple Sequence Repeat (inter-SSR) PCR for quantitation of tumor genomic instability. Associations between genomic instability level and known breast cancer prognostic factors were evaluated using the Pearson Product Moment Correlation, the Kruskal-Wallis test of independent samples and the Mann-Whitney non-parametric test. Genomic instability was detected by inter-SSR PCR in over 90% of the breast tumors. The mean instability index was 3.08% (0-7.59%), approximately the same mean value observed in studies of colorectal and thyroid carcinomas. Significantly higher levels of instability were associated with tumors exhibiting necrosis. Genomic instability as measured is detected in the majority of breast cancers at levels comparable to other tumor types. Hypoxia, such as that observed in necrotic regions of tumors, has been associated with elevated genomic damage. We hypothesize that the higher levels of genomic instability detected in necrotic tumors is a consequence of hypoxia-associated DNA damage.

Genomic instability in invasive breast carcinoma measured by inter-Simple Sequence Repeat PCR. Publishing Authors By Initials

DL Stoler,JD Bartos,H Swede,SB Edge,JS Winston,SM Wiseman,GR Anderson,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: repetitive sequences, nucleic acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: repetitive sequences, nucleic acid research

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MEDLINE DATE:

Genomic instability in invasive breast carcinoma measured by inter-Simple Sequence Repeat PCR. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Breast cancer research and treatment

VOLUME: 97

Page Numbers: 107-10

Journal Abbreviation: Breast Cancer Res. Treat.

ISSN: 0167-6806

DAY: 3

MONTH: May

YEAR: 2006

Genomic instability in invasive breast carcinoma measured by inter-Simple Sequence Repeat PCR. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8111104

Genomic instability in invasive breast carcinoma measured by inter-Simple Sequence Repeat PCR. Keywords Mesh Terms:

KEYWORDS: Repetitive Sequences, Nucleic Acid

MESH TERMS: genetics

Chemical & Substance for Abstract: Genomic instability in invasive breast carcinoma measured by inter-Simple Sequence Repeat PCR. Information

Substance Name: DNA, Neoplasm

Registry Number: 0

Grant and Affiliation Information for Genomic instability in invasive breast carcinoma measured by inter-Simple Sequence Repeat PCR.

AFFILIATION: Department of Cancer Pathology and Prevention, Roswell Park Cancer Institute, Buffalo, NY, USA.

Country: Netherlands

AGENCY: United States NCI

GRANT: R01 CA74127

ACRONYM: CA

MEDLINETA: Breast Cancer Res Treat

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