Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors.

Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors. Research Abstract Details 

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Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors. Abstract Text:

Henri L Saenz,Philipp Engel, Stoeckli,Christa Lanz, Raddatz,Muriel Vayssier-Taussat,Richard Birtles,Stephan C Schuster,Christoph Dehio,Henri L Saenz,Philipp Engel, Stoeckli,Christa Lanz, Raddatz,Muriel Vayssier-Taussat,Richard Birtles,Stephan C Schuster,Christoph Dehio,

The bacterial genus Bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. Bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. Here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. We determined the complete genome sequence of Bartonella tribocorum by shotgun sequencing and functionally identified 97 pathogenicity genes by signature-tagged mutagenesis. Eighty-one pathogenicity genes belong to the core genome (1,097 genes) of the radiating lineage inferred from genome comparison of B. tribocorum, Bartonella henselae and Bartonella quintana. Sixty-six pathogenicity genes are present in B. bacilliformis, and one has been lost by deletion. The 14 pathogenicity genes specific for the radiating lineage encode two laterally acquired type IV secretion systems, suggesting that these systems have a role in host adaptability.

Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors. Publishing Authors By Initials

HL Saenz,P Engel,MC Stoeckli,C Lanz,G Raddatz,M Vayssier-Taussat,R Birtles,SC Schuster,C Dehio,HL Saenz,P Engel,MC Stoeckli,C Lanz,G Raddatz,M Vayssier-Taussat,R Birtles,SC Schuster,C Dehio,

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Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature genetics

VOLUME: 39

Page Numbers: 1469-76

Journal Abbreviation: Nat. Genet.

ISSN: 1546-1718

DAY: 25

MONTH: 11

YEAR: 2007

Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors. Information

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LANGUAGE: eng

NlmUniqueID: 9216904

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Grant and Affiliation Information for Genomic analysis of Bartonella identifies type IV secretion systems as host adaptability factors.

AFFILIATION: Focal Area Infection Biology, Biozentrum, University of Basel, CH-4056 Basel, Switzerland.

Country: United States

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MEDLINETA: Nat Genet

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