Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes.

Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. Research Abstract Details 

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Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. Abstract Text:

Xiao-Jian Sun,Peng-Fei Xu,Ting Zhou,Ming Hu,Chun-Tang Fu,Yong Zhang,Yi Jin,Yi Chen,Sai-Juan Chen,Qiu-Hua Huang,Ting Xi Liu,Zhu Chen,

SET domain-containing proteins represent an evolutionarily conserved family of epigenetic regulators, which are responsible for most histone lysine methylation. Since some of these genes have been revealed to be essential for embryonic development, we propose that the zebrafish, a vertebrate model organism possessing many advantages for developmental studies, can be utilized to study the biological functions of these genes and the related epigenetic mechanisms during early development. To this end, we have performed a genome-wide survey of zebrafish SET domain genes. 58 genes total have been identified. Although gene duplication events give rise to several lineage-specific paralogs, clear reciprocal orthologous relationship reveals high conservation between zebrafish and human SET domain genes. These data were further subject to an evolutionary analysis ranging from yeast to human, leading to the identification of putative clusters of orthologous groups (COGs) of this gene family. By means of whole-mount mRNA in situ hybridization strategy, we have also carried out a developmental expression mapping of these genes. A group of maternal SET domain genes, which are implicated in the programming of histone modification states in early development, have been identified and predicted to be responsible for all known sites of SET domain-mediated histone methylation. Furthermore, some genes show specific expression patterns in certain tissues at certain stages, suggesting the involvement of epigenetic mechanisms in the development of these systems. These results provide a global view of zebrafish SET domain histone methyltransferases in evolutionary and developmental dimensions and pave the way for using zebrafish to systematically study the roles of these genes during development.

Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. Publishing Authors By Initials

XJ Sun,PF Xu,T Zhou,M Hu,CT Fu,Y Zhang,Y Jin,Y Chen,SJ Chen,QH Huang,TX Liu,Z Chen,

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Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: PLoS ONE

VOLUME: 3

Page Numbers: e1499

Journal Abbreviation: PLoS ONE

ISSN: 1932-6203

DAY: 30

MONTH: 01

YEAR: 2008

Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes.

AFFILIATION: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Country: United States

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MEDLINETA: PLoS ONE

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