Genome wide screening of CAG trinucleotide repeat lengths in breast cancer.

Genome wide screening of CAG trinucleotide repeat lengths in breast cancer. Research Abstract Details 

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Genome wide screening of CAG trinucleotide repeat lengths in breast cancer. Abstract Text:

Hamdi Jarjanazi,Hong Li,Irene L Andrulis,Hilmi Ozcelik,

Trinucleotide repeat sequences are widely present in the human genome. The expansion of CAG repeats have been studied very extensively, and shown to be the causative mechanism of more than 40 neuromuscular and neurodegenerative diseases. In the present study, we performed a genome wide screening of CAG repeat expansions in non-neoplastic tissues of 212 breast cancer cases and 196 healthy population controls using the Repeat Expansion Detection (RED) method. Distribution of CAG repeat lengths in cases was not significantly different from controls. However, dramatically expanded CAG repeats were detected in 2.4% (n=5) of breast cancer cases where no repeats of similar size were detected in any of the healthy population controls. Although this trend shows only borderline significance (p=0.06), this finding suggests a potential involvement of CAG repeat expansion in breast cancer susceptibility. These repeats may potentially affect the function of cancer predisposition genes, with a similar mechanism as in neurodegenerative and neuromuscular disorders.

Genome wide screening of CAG trinucleotide repeat lengths in breast cancer. Publishing Authors By Initials

H Jarjanazi,H Li,IL Andrulis,H Ozcelik,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: repetitive sequences, nucleic acid: tandem repeat sequences: microsatellite repeats: trinucleotide repeats research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: base sequence: repetitive sequences, nucleic acid: tandem repeat sequences: microsatellite repeats: trinucleotide repeats research

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Genome wide screening of CAG trinucleotide repeat lengths in breast cancer. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Disease markers

VOLUME: 22

Page Numbers: 343-9

Journal Abbreviation: Dis. Markers

ISSN: 0278-0240

DAY: 3

MONTH: 12

YEAR: 2006

Genome wide screening of CAG trinucleotide repeat lengths in breast cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8604127

Genome wide screening of CAG trinucleotide repeat lengths in breast cancer. Keywords Mesh Terms:

KEYWORDS: Trinucleotide Repeats

MESH TERMS: methods

Chemical & Substance for Abstract: Genome wide screening of CAG trinucleotide repeat lengths in breast cancer. Information

Substance Name: Genetic Markers

Registry Number: 0

Grant and Affiliation Information for Genome wide screening of CAG trinucleotide repeat lengths in breast cancer.

AFFILIATION: F. Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research Institute and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ont., Canada.

Country: Netherlands

AGENCY: United States NCI

GRANT: CA-95-003

ACRONYM: CA

MEDLINETA: Dis Markers

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