Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)).

Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)). Research Abstract Details 

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Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)). Abstract Text:

Vihas T Vasu,Brad Hobson,Kishorchandra Gohil,Carroll E Cross,

Alpha-tocopherol transfer protein (ATTP) null mice (ATTP(-/-)) have a systemic deficiency of alpha-tocopherol (AT). The heart AT levels of ATTP(-/-) are <10% of those in ATTP(+/+) mice. The genomic responses of heart to AT deficiency were determined in 3 months old male ATTP(-/-) mice and compared with their ATTP(+/+) littermate controls using Affymetrix 430A 2.0 high density oligonucleotide arrays. Differential analysis of approximately 13000 genes identified repression of genes related to immune system and activation of genes related to lipid metabolism and inflammation with no significant change in the expression of classical antioxidant genes (catalase, superoxide dismutase, glutathione peroxidase) in ATTP(-/-) as compared to ATTP(+/+) mice. The present data identifies novel classes of AT sensitive genes in heart tissue.

Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)). Publishing Authors By Initials

VT Vasu,B Hobson,K Gohil,CE Cross,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e: tocopherols: alpha-tocopherol research

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Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)). Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: FEBS letters

VOLUME: 581

Page Numbers: 1572-8

Journal Abbreviation:

ISSN: 0014-5793

DAY: 15

MONTH: 03

YEAR: 2007

Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)). Information

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LANGUAGE: eng

NlmUniqueID: 155157

Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)). Keywords Mesh Terms:

KEYWORDS: alpha-Tocopherol

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)). Information

Substance Name: alpha-Tocopherol

Registry Number: 59-02-9

Grant and Affiliation Information for Genome-wide screening of alpha-tocopherol sensitive genes in heart tissue from alpha-tocopherol transfer protein null mice (ATTP(-/-)).

AFFILIATION: Department of Internal Medicine, Centre for Comparative Respiratory Biology and Medicine, Genome and Biomedical Sciences Facility, Lab 6404A, 451 East Health Sciences Drive, UC Davis, Davis, CA 95616, USA.

Country: Netherlands

AGENCY: United States NIEHS

GRANT: ES 011985

ACRONYM: ES

MEDLINETA: FEBS Lett

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