Genome-wide linkage analysis of 160 North American families with celiac disease.

Genome-wide linkage analysis of 160 North American families with celiac disease. Research Abstract Details 

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Genome-wide linkage analysis of 160 North American families with celiac disease. Abstract Text:

C P Garner,Y C Ding,L Steele,L Book,K Leiferman,J J Zone,S L Neuhausen,

Celiac disease (CD) is a common autoimmune disease caused by exposure to the protein gliadin in wheat, and related prolamins in barley and rye. The prevalence of the disease in the US is 1:133. The aim of this study was to identify non-human leukocyte antigen (HLA) loci that predispose to CD. A genome-wide search of 405 microsatellite markers was performed on DNA samples from 160 families with a minimum of two cases of CD. Multipoint, parametric and non-parametric linkage (NPL) analyses were performed. Locations on chromosomes 1q, 3q, 6p, 6q, 7q, 9q and 10q showed linkage statistics (NPL scores or heterogeneity logarithm of the odds (HLOD) scores) of approximately 2.0 or larger. The greatest evidence for linkage outside of chromosome 6 was on 7q and 9q. An NPL score of 2.60 occurred at position 151.0 on 7q and a HLOD score of 2.47 occurred at position 144.8 on 9q under a recessive model. As expected, there was highly significant linkage to the HLA region on 6p, with NPL and HLOD scores exceeding 5.50. In conclusion, this genome-wide linkage analysis represents one of the largest such studies of CD. The most promising region is a putative locus on 7q, a region reported independently in previous genome-wide searches.

Genome-wide linkage analysis of 160 North American families with celiac disease. Publishing Authors By Initials

CP Garner,YC Ding,L Steele,L Book,K Leiferman,JJ Zone,SL Neuhausen,

For similar geographic locations: americas: north america research abstracts see: geographic locations: americas: north america research

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Genome-wide linkage analysis of 160 North American families with celiac disease. Journal Published:

PUBLICATION TYPE: Review

Journal: Genes and immunity

VOLUME: 8

Page Numbers: 108-14

Journal Abbreviation: Genes Immun.

ISSN: 1466-4879

DAY: 30

MONTH: 11

YEAR: 2006

Genome-wide linkage analysis of 160 North American families with celiac disease. Information

Number of References: 45

LANGUAGE: eng

NlmUniqueID: 100953417

Genome-wide linkage analysis of 160 North American families with celiac disease. Keywords Mesh Terms:

KEYWORDS: North America

MESH TERMS: genetics

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Grant and Affiliation Information for Genome-wide linkage analysis of 160 North American families with celiac disease.

AFFILIATION: Division of Epidemiology, Department of Medicine, University of California Irvine, Irvine, CA 92697-7550, USA.

Country: England

AGENCY: United States NHGRI

GRANT: N01-HG-65403

ACRONYM: HG

MEDLINETA: Genes Immun

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