Genome-wide association analysis identifies 20 loci that influence adult height.

Genome-wide association analysis identifies 20 loci that influence adult height. Research Abstract Details 

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Genome-wide association analysis identifies 20 loci that influence adult height. Abstract Text:

Adult height is a model polygenic trait, but there has been limited success in identifying the genes underlying its normal variation. To identify genetic variants influencing adult human height, we used genome-wide association data from 13,665 individuals and genotyped 39 variants in an additional 16,482 samples. We identified 20 variants associated with adult height (P < 5 x 10(-7), with 10 reaching P < 1 x 10(-10)). Combined, the 20 SNPs explain approximately 3% of height variation, with a approximately 5 cm difference between the 6.2% of people with 17 or fewer 'tall' alleles compared to the 5.5% with 27 or more 'tall' alleles. The loci we identified implicate genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes. Finally, our results provide insights into the genetic architecture of a classic quantitative trait.

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Genome-wide association analysis identifies 20 loci that influence adult height. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nature genetics

VOLUME: 40

Page Numbers: 575-83

Journal Abbreviation: Nat. Genet.

ISSN: 1546-1718

DAY: 6

MONTH: 04

YEAR: 2008

Genome-wide association analysis identifies 20 loci that influence adult height. Information

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LANGUAGE: eng

NlmUniqueID: 9216904

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Grant and Affiliation Information for Genome-wide association analysis identifies 20 loci that influence adult height.

AFFILIATION: Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK.

Country: United States

AGENCY: United Kingdom Wellcome T

GRANT: PG02/128

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MEDLINETA: Nat Genet

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