Genome-scale transcript analyses in human neutrophils.

Genome-scale transcript analyses in human neutrophils. Research Abstract Details 

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Genome-scale transcript analyses in human neutrophils. Abstract Text:

Transcriptome analyses of single- and multicellular organisms have changed fundamental understanding of biological and pathological processes across multiple scientific disciplines. Over the past 5 yr, studies of polymorphonuclear leukocyte (or neutrophil) (PMN) gene expression on a global scale have provided new insight into the molecular processes that promote resolution of infections in humans. Herein, we present methods to analyze gene expression in human neutrophils using Affymetrix oligonucleotide microarrays, which include isolation of high-quality RNA, generation and labeling of cRNA, and GeneChip hybridization and scanning. Notably, the procedures utilize commercially available reagents and materials and thus represent a standardized approach for evaluating PMN transcript levels.

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Genome-scale transcript analyses in human neutrophils. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Methods in molecular biology (Clifton, N.J.)

VOLUME: 412

Page Numbers: 441-53

Journal Abbreviation: Methods Mol. Biol.

ISSN: 1064-3745

DAY: 5

MONTH: 05

YEAR: 2007

Genome-scale transcript analyses in human neutrophils. Information

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LANGUAGE: eng

NlmUniqueID: 9214969

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Grant and Affiliation Information for Genome-scale transcript analyses in human neutrophils.

AFFILIATION: Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID, USA.

Country: United States

AGENCY: United States NCRR

GRANT: P20RR015587

ACRONYM: RR

MEDLINETA: Methods Mol Biol

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