Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production.

Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production. Abstract Text:

Satoko Takeuchi,Takashi Goto,Ken-Ichiro Mikami,Kouichi Miura,Shigetoshi Ohshima,Kazuo Yoneyama,Michiko Sato,Tomomi Shibuya,Daisuke Watanabe,Ei Kataoka,Daisuke Segawa,Ayako Endo,Wataru Sato,Ryutaro Yoshino,Sumio Watanabe,

Genipin is a metabolite derived from the herbal medicine Inchinko-to. Little is known about the mechanism of genipin action on acute liver injury through inflammatory cytokines. We examined the effects of genipin on production of TNF-alpha in vivo and in vitro. Mice were given GalN/LPS with or without genipin treatment. All mice not given genipin died within 12h. But in mice given genipin, 8 of 15 mice survived for 24h after GalN/LPS administration. Histologically, hepatic necrosis and inflammatory cells infiltration were significantly slight in mice given genipin. Serum AST and ALT activity were significantly lower in mice given genipin. Serum and liver homogenate TNF-alpha levels were significantly lower in mice given genipin. However, in IL-6 and IL-1beta, there were no significant differences in mice given and not given genipin. TNF-alpha, NF-kappaB activation and TNF-alpha mRNA expression in a cultured mouse macrophage-like cell line J774.1 were significantly suppressed by genipin administration. In conclusion, the present findings suggest that genipin, a metabolite derived form the herbal medicine Inchinko-to improved acute liver dysfunction by suppressive effect of TNF-alpha production.

Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production. Publishing Authors By Initials

S Takeuchi,T Goto,K Mikami,K Miura,S Ohshima,K Yoneyama,M Sato,T Shibuya,D Watanabe,E Kataoka,D Segawa,A Endo,W Sato,R Yoshino,S Watanabe,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 33

Page Numbers: 298-305

Journal Abbreviation:

ISSN: 1386-6346

DAY: 16

MONTH: 11

YEAR: 2005

Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9711801

Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production.

AFFILIATION: Department of Gastroenterology, Akita University School of Medicine, 1-1-1 Hondo, Akita 010-8543, Japan.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hepatol Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production Related Publications

• Analysis of the CC chemokine receptor 5 delta32 polymorphism in a Brazilian population with cutaneous leishmaniasis.
• Behavioral Determination of Odor Preference is Coded by the Oscillation Frequency in a Collective Oscillating Network of a Terrestrial Mollusk.
• Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3cm or less in diameter.
• Decreased renal expressions of heat shock protein-72 and -25 are associated with renal dysfunction in biliary cirrhotic rats.
• Design of a synchrotron radiation source at Tohoku University.
• Divergent activities of interferon-alpha subtypes against intracellular hepatitis C virus replication.
• Effect of the moderate exercise on performance in upper/lower limb during long term bed rest.
• Effects of aminoglutethimide phosphate on litter size and birth weight in superovulated rats.
• Efficacy of ecabet sodium enema on steroid resistant or steroid dependent ulcerative colitis.
• Efficient Gene Transfer into Differentiated Human Trophoblast Cells with Adenovirus Vector Containing RGD Motif in the Fiber Protein.
• Enhancement of cytoprotective ability and cell restoration in 70-kDa heat shock protein gene-transfected rat gastric mucosal cells.
• Epimorphin expression and stellate cell status in mouse liver injury.
• Establishment of a novel chondrocytic cell line N1511 derived from p53-null mice.
• Genipin prevents fulminant hepatic failure resulting in reduction of lethality through the suppression of TNF-alpha production.
• Heart rate turbulence slope reduction in imminent ventricular tachyarrhythmia and its implications.
• Hepatic gene expression in hepatocyte-specific Pten deficient mice showing steatohepatitis without ethanol challenge.
• High-performance EUV/soft X-ray ellipsometry system using multilayer mirrors.
• Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1 gene effectively suppresses the growth of pre-existing tumors.
• Mucins and ocular surface disease.
• Optical design for a bending-magnet beamline based on a varied-line-spacing plane grating.
• Proline promoted synthesis of ring-fused homodimers: self-condensation of alpha,beta-unsaturated aldehydes.
• Pyocyanin isolated from a marine microbial population: synergistic production between two distinct bacterial species and mode of action.
• Root caries prevalence in a group of Brazilian adult dental patients.
• Scrotal imaging.
• Synthesis and biological activity of 5',9-anhydro-3-purine-isonucleosides as potential anti-hepatitis C virus agents.
• Technical note: measurement of ferritin in bovine milk and its clinical significance.
• Transmission multilayer polarizers for use in the 55-90 eV region.
• Treatment for intercostal arterial aneurysm in neurofibromatosis type 1.
• Two cases requiring external reinforcement in perceptual learning.
• Well-differentiated adenocarcinoma mimicking complete-type intestinal metaplasia in the stomach.