Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias.

Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias. Research Abstract Details 

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Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias. Abstract Text:

Constantine A Stratakis,Sosipatros A Boikos,

Adrenocortical causes of Cushing's syndrome include the following: common cortisol-producing adenomas, which are usually isolated (without associated tumors) and sporadic (without a family history); rare, but often clinically devastating, adrenocortical carcinomas; and a spectrum of adrenocorticotropin-independent, and almost always bilateral, hyperplasias, which are not rare, and are the most recently recognized cause. The majority of benign lesions of the adrenal cortex seem to be linked to abnormalities of the cyclic AMP signaling pathway, whereas cancer is linked to aberrant expression of insulin-like growth factor II, tumor protein p53 and related molecules. In this article, we propose a new clinical classification and nomenclature for the various forms of adrenocorticotropin-independent adrenocortical hyperplasias that is based on their histologic and genetic features. We also review the molecular genetics of adrenocortical tumors, including recent discoveries relating to the role of phosphodiesterase 11A. This is a timely Review because of recent advances in the clinical and molecular understanding of these diseases.

Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias. Publishing Authors By Initials

CA Stratakis,SA Boikos,

For similar pathological conditions, signs and symptoms: pathologic processes: hyperplasia research abstracts see: pathological conditions, signs and symptoms: pathologic processes: hyperplasia research

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Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias. Journal Published:

PUBLICATION TYPE: Review

Journal: Nature clinical practice. Endocrinology & metaboli

VOLUME: 3

Page Numbers: 748-57

Journal Abbreviation:

ISSN: 1745-8374

DAY: 30

MONTH: Nov

YEAR: 2007

Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias. Information

Number of References: 68

LANGUAGE: eng

NlmUniqueID: 101261798

Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias. Keywords Mesh Terms:

KEYWORDS: Hyperplasia

MESH TERMS: pathology

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Grant and Affiliation Information for Genetics of adrenal tumors associated with Cushing's syndrome: a new classification for bilateral adrenocortical hyperplasias.

AFFILIATION: Heritable Disorders Branch, National Institute of Child Health and Human Development (NICHD), National Institutes for Health (NIH), Bethesda, MD 20892, USA. stratakc@mail.nih.gov

Country: England

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MEDLINETA: Nat Clin Pract Endocrinol Meta

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